Evidence map›Paper›PMID 34095868›Full record

ArticleSTAR protocols2021

One-step CRISPR-Cas9 protocol for the generation of plug & play conditional knockouts in

Joyce J S Yu, Jean-Paul Vincent, Ian J McGough

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joyce J S YuThe Francis Crick Institute, London NW1 1AT, UK.
Jean-Paul VincentThe Francis Crick Institute, London NW1 1AT, UK.
Ian J McGoughThe Francis Crick Institute, London NW1 1AT, UK.
The Francis Crick Institute · GB

Funding

Cancer Research UK FC001204Wellcome Trust 206341/Z/17/Z
6 · The paper itself

Abstract

This one-step method generates, for any locus, a conditional knockout allele in

Indexed as

CRISPR-Cas SystemsGene Knockdown TechniquesAllelesAnimalsDrosophila melanogasterGene EditingCRISPRGeneticsModel Organisms

Identifiers

PMID34095868
PMCPMC8165570
OpenAlexW3165591293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.