Evidence map›Paper›PMID 34095859›Full record

ArticleSTAR protocols2021

Protocol for constructing large size human antibody heavy chain variable domain (V

Chuan Chen, Zehua Sun, Xianglei Liu, Wei Li, Dimiter S Dimitrov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. AI-based IsAb2.0 for antibody design.Briefings in bioinformatics · 2024
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chuan ChenCenter for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Zehua SunCenter for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Xianglei LiuCenter for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Wei LiCenter for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Dimiter S DimitrovCenter for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
University of Pittsburgh · USAbound Bio (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This protocol is a comprehensive guide to phage display-based selection of virus neutralizing V

Indexed as

Peptide LibraryAmino Acid SequenceAntibodies, NeutralizingAntibodies, ViralBase SequenceCell Surface Display TechniquesCOVID-19HumansImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionSARS-CoV-2Sequence HomologyAntibodies, NeutralizingAntibodies, ViralImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionPeptide LibraryAntibodyCell cultureHigh Throughput ScreeningImmunologyMicrobiologyMolecular BiologyProtein expression and purification

Identifiers

PMID34095859
PMCPMC8164376
OpenAlexW3172289959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.