Evidence map›Paper›PMID 34095845›Full record

ArticleRSC medicinal chemistry2020

Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2.

R Kirk, A Ratcliffe, G Noonan, M Uosis-Martin, D Lyth, O Bardell-Cox, J Massam, P Schofield, A Lyons, D Clare and 15 more

Open access · bronzeAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 1 institution in 1 country.

R KirkRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.ORCID https://orcid.org/0000-0002-3858-8650
A RatcliffeRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
G NoonanRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
M Uosis-MartinRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
D LythRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
O Bardell-CoxRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
J MassamRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
P SchofieldRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
A LyonsRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
D ClareRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
J MacleanRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
A SmithRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
V SavageRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.ORCID https://orcid.org/0000-0002-5381-0731
S MohmedRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
C CharrierRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
A-M SalisburyRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
E MoyoRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
N OoiRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
N Chalam-JudgeRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
J CheungRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
N R StokesRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.ORCID https://orcid.org/0000-0001-9984-6521
S BestRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
M CraigheadRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
R ArmerRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.
A HuxleyRedx Anti-Infectives Ltd Alderley Park Macclesfield SK10 4TG Cheshire UK.ORCID https://orcid.org/0000-0003-3044-6575
Macclesfield College · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Building on our previously-reported novel tricyclic topoisomerase inhibitors (NTTIs), we disclose the discovery of REDX07965, which has an MIC

Identifiers

PMID34095845
PMCPMC8126889
OpenAlexW3087359010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.