Evidence map›Paper›PMID 34095834›Full record

ArticleBrain communications2021

Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease.

Enmanuelle Pardilla-Delgado, Heirangi Torrico-Teave, Justin S Sanchez, Liliana A Ramirez-Gomez, Ana Baena, Yamile Bocanegra, Clara Vila-Castelar, Joshua T Fox-Fuller, Edmarie Guzmán-Vélez, Jairo Martínez and 4 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  3. Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Enmanuelle Pardilla-DelgadoMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Heirangi Torrico-TeaveMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Justin S SanchezMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0003-4421-3078
Liliana A Ramirez-GomezMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ana BaenaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin 050010, Colombia.
Yamile BocanegraGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin 050010, Colombia.
Clara Vila-CastelarMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Joshua T Fox-FullerMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Edmarie Guzmán-VélezMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jairo MartínezMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Sergio AlvarezHospital Pablo Tobon Uribe, Medellin 050034, Colombia.
Martin Ochoa-EscuderoHospital Pablo Tobon Uribe, Medellin 050034, Colombia.
Francisco LoperaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin 050010, Colombia.
Yakeel T QuirozMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0001-9714-8244
Harvard University · USUniversidad de Antioquia · COHospital Pablo Tobon Uribe · COBoston University · US

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Sudeshna Das · 2019 to 2026
$36.5M
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's diseaseR01AG054671 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2017 to 2021
$3.8M
Memory network dysfunction as an early marker of preclinical Alzheimer's DiseaseDP5OD019833 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2014 to 2018
$2.3M
Aerobic fitness as a modifier of neurodegeneration and cognitive decline in preclinical Alzheimer's diseaseK23AG061276 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GUZMÁN-VÉLEZ, EDMARIE · 2019 to 2023
$881k
NHLBI NIH HHS T32 HL007901NIA NIH HHS K23 AG061276NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG054671NIH HHS DP5 OD019833
6 · The paper itself

Abstract

Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer's disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of

Indexed as

MRIPET imagingpreclinicalpresenilin-1thalamus

Identifiers

PMID34095834
PMCPMC8172494
OpenAlexW3161562376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.