Evidence map›Paper›PMID 34095726›Full record

ArticleAnnals of gastroenterological surgery2021

Impact of postoperative complications after primary tumor resection on survival in patients with incurable stage IV colorectal cancer: A multicenter retrospective cohort study.

Yusuke Fujita, Koya Hida, Nobuaki Hoshino, Yoshiharu Sakai, Tsuyoshi Konishi, Akiyoshi Kanazawa, Michitoshi Goto, Shuji Saito, Tadashi Suda, Masahiko Watanabe and 1 more

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In one paragraph

Article in Annals of gastroenterological surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Yusuke FujitaDepartment of Surgery Kyoto University Graduate School of Medicine Kyoto Japan.ORCID https://orcid.org/0000-0002-4679-7065
Koya HidaDepartment of Surgery Kyoto University Graduate School of Medicine Kyoto Japan.ORCID https://orcid.org/0000-0001-7210-7075
Nobuaki HoshinoDepartment of Surgery Kyoto University Graduate School of Medicine Kyoto Japan.ORCID https://orcid.org/0000-0002-7171-8971
Yoshiharu SakaiDepartment of Surgery Osaka Red Cross Hospital Osaka Japan.
Tsuyoshi KonishiDepartment of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA.
Akiyoshi KanazawaDepartment of Surgery Shimane Prefectural Central Hospital Shimane Japan.
Michitoshi GotoDepartment of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan.
Shuji SaitoDivision of Surgery Gastrointestinal Center Yokohama Shin-Midori General Hospital Yokohama Japan.
Tadashi SudaSuda Medical Clinic Kawasaki Japan.
Masahiko WatanabeDepartment of Surgery Kitasato University School of Medicine Kanagawa Japan.
Japan Society of Laparoscopic Colorectal Surgery
Kyoto University · JPJuntendo University · JPKitasato University · JPOsaka Red Cross Hospital · JPShimane Prefectural Central Hospital · JPShioda General Hospital · JPThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPrimary tumor resection for patients with incurable stage IV colorectal cancer can prevent tumor-related complications but may cause postoperative complications. Postoperative complications delay the administration of chemotherapy and can lead to the spread of malignancy. However, the impact of postoperative complications after primary tumor resection on survival in patients with incurable stage IV colorectal cancer remains unclear. Therefore, this study aimed to investigate how postoperative complications after primary tumor resection affect survival in this patient group.

methodsWe reviewed data on 966 patients with stage IV colorectal cancer who underwent palliative primary tumor resection between January 2006 and December 2007. We examined the association between major complications (National Cancer Institute Common Terminology Criteria for Adverse Events v3.0 grade 3 or more) and overall survival using Cox proportional hazard model and explored risk factors associated with major complications using multivariable logistic regression analysis.

resultsNinety-three patients (9.6%) had major complications. The 2-year overall survival rate was 32.7% in the group with major complications and 50.3% in the group with no major complications. Patients with major complications had a significantly poorer prognosis than those without major complications (hazard ratio: 1.62; 95% confidence interval: 1.21-2.18;

conclusionsPostoperative complications after primary tumor resection was associated with decreased long-term survival in patients with incurable stage IV colorectal cancer.

Indexed as

colorectal neoplasmscomplicationprimary tumor resectionstage IVsurvival

Identifiers

PMID34095726
PMCPMC8164466
OpenAlexW3124204242

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.