ArticleClinical orthopaedics and related research1988
Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head.
Article in Clinical orthopaedics and related research, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Alcohol intake and the risk of osteonecrosis of the femoral head in Japanese populations: a dose-response meta-analysis of case-control studies.Clinical rheumatology · 2017Pooled it
- A meta-analysis of the effects of cigarette smoking on bone mineral density.Calcified tissue international · 2001Pooled it
- Multifocal Glucocorticoid-Associated Osteonecrosis: Clinical Characteristics and Systemic Molecular Features.Biomedicines · 2026Article
- Incidence and risk factors for fixation failure of femoral neck fractures in adults: a single-center multifactorial analysis.Langenbeck's archives of surgery · 2026Article
- Behçet's disease and avascular necrosis of the knees: a case report.Annals of medicine and surgery (2012) · 2026Article
- Altered lineage commitment of bone marrow mesenchymal stem cells in idiopathic osteonecrosis of the femoral head.World journal of orthopedics · 2025Article
- The bibliometric and visualization analysis of alcohol-induced osteonecrosis of the femoral head: research trends and future directions (1998-2024).Journal of orthopaedic surgery and research · 2025Article
- Efficacy of teriparatide and factors for the collapse of femoral head following femoral curved varus osteotomy.Journal of hip preservation surgery · 2025Article
- Bilateral avascular necrosis: A rare complication of Fabry disease.Molecular genetics and metabolism reports · 2025Article
- Can Knee Arthroscopy Be Considered Entirely Safe for Patients Over 50 Years Old With no Risk of Osteonecrosis? Case Series and Literature Review on Post-Artrhoscopy Osteonecrosis of the Knee (PAONK).Orthopaedic surgery · 2025Review
- Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse.Scientific reports · 2024Article
- Atraumatic osteonecrosis of the humeral head: pathophysiology and current concepts of evaluation and treatment.JSES reviews, reports, and techniques · 2022Review
- Osteonecrosis of the Femoral Head.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Article
- The polymorphisms of MIR31HG gene is correlated with alcohol-induced osteonecrosis of the femoral head in Chinese Han male population.Frontiers in endocrinology · 2022Article
- The humeral head: A review of the blood supply and possible link to osteonecrosis following rotator cuff repair.Journal of anatomy · 2021Review
- Short to mid-term outcome of total hip arthroplasty with cementless implants in patients younger than 25 years old.Der Orthopade · 2021Article
- Evaluation of whole-body modalities for diagnosis of multifocal osteonecrosis-a pilot study.Arthritis research & therapy · 2021Article
- Article
- Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population.BMC musculoskeletal disorders · 2020Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An epidemiologic study compared 112 patients with idiopathic osteonecrosis (ON) of the femoral head having no history of systemic corticosteroid use and 168 hospital controls. Patients and controls were matched for gender, age, ethnicity, hospital, and time of initial diagnosis. The role of alcohol intake, cigarette smoking, and occupational status was assessed in relation to the development of ON. The relative risk (RR), the measure of association between ON and the risk factors, was statistically adjusted for the potential confounding effects of other factors by the conditional logistic regression model. An elevated risk for regular drinkers (RR = 7.8, p less than 0.001) and a clear dose-response relationship was noted (test for trend; p less than 0.001): the RRs were 3.3, 9.8, and 17.9 for current consumers of less than 400, 400-1000, and greater than or equal to 1000 ml/week of alcohol, respectively. A significantly increased risk was found for current smokers (RR = 3.9; p less than 0.05). However, the cumulative effect of smoking was not evident. No increased risk was found for obesity or for heavy physical work. Regarding causation of ON, this study confirmed the consistent association with excessive alcohol intake and suggested the immediate untoward effects of smoking. The role of heavy physical work as a form of mechanical stress was not correlated with ON.
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3409564W2047099337What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.