Evidence map›Paper›PMID 34095632›Full record

ArticleJACC. Basic to translational science2021

Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine.

Juan F Granada, Marco Ferrone, Gilberto Melnick, Lesley Crookall, Daniel Schulz-Jander, Stefan Tunev, Robert J Melder, Grzegorz L Kaluza

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Drug-eluting devices for lower limb peripheral arterial disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Juan F GranadaCRF Skirball Center for Innovation, Orangeburg, New York, USA.
Marco FerroneCRF Skirball Center for Innovation, Orangeburg, New York, USA.
Gilberto MelnickCRF Skirball Center for Innovation, Orangeburg, New York, USA.
Lesley CrookallMedtronic CardioVascular, Santa Rosa, California, USA.
Daniel Schulz-JanderMedtronic CardioVascular, Santa Rosa, California, USA.
Stefan TunevMedtronic CardioVascular, Santa Rosa, California, USA.
Robert J MelderMedtronic CardioVascular, Santa Rosa, California, USA.
Grzegorz L KaluzaCRF Skirball Center for Innovation, Orangeburg, New York, USA.
Center for Innovation · USComprehensive Cardiovascular · USMedtronic (United States) · USHospital de Clínicas Universidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The authors evaluated the presence of paclitaxel and healing of distal hind limb wounds created in 27 swine using biopsy punches followed by paclitaxel-coated balloon (PCB) use in the iliofemoral arteries of healthy swine. After 14 and 28 days, no differences were seen in time course, appearance, and histopathology of wound healing between the single or triple PCB and uncoated balloon treatment despite clinically relevant paclitaxel concentrations in the skin adjacent to the healing wounds. Presence of paclitaxel downstream from the PCB treatment site does not impair the wound healing response of preexisting distal cutaneous lesions in healthy swine.

Indexed as

BTK, below the kneeCLI, critical limb ischemiahistopathologypaclitaxel-coated balloonPCB, paclitaxel coated balloonPTA, percutaneous transluminal angioplastySFA, superficial femoral arteryswinetranslationalwound healing

Identifiers

PMID34095632
PMCPMC8165120
OpenAlexW3148164654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.