ArticleBioactive materials2021
Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Curative efficacy of surgical procedures for older patients with femoral neck fracture: a network meta-analysis and systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- An AI-integrated organoid platform enables high-throughput functional evaluation of bioactive metal ions.Bioactive materials · 2026Article
- Biodegradable Zn-Based Implants: Progress, Challenges, and Pathways toward Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Biomechanical evaluation of biodegradable zinc and polylactide pins for radial head fracture fixation: a human cadaver study.Journal of orthopaedic surgery and research · 2026Article
- Synergistic Low-Intensity Pulsed Ultrasound-Activated Vancomycin-Loaded Microbubbles for MRSA Biofilm Eradication and Bone Regeneration in Periprosthetic Joint Infection.ACS biomaterials science & engineering · 2026Article
- Impact of NbACS omega · 2026Article
- A long-term quasi-equivalentBioactive materials · 2025Article
- Biomechanical analysis of biodegradable magnesium, zinc, and polylactide pins for fixation of radial head fractures.Journal of orthopaedic surgery and research · 2025Article
- Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration.Bioactive materials · 2025Review
- Effect of Combined Equal-Channel Angular Pressing and Rolling on the Microstructure and Mechanical Properties of Zn-0.5Ag-0.2Mg Alloy.Materials (Basel, Switzerland) · 2025Article
- Nanohybrid Hydrogel with Dual Functions: Controlled Low-Temperature Photothermal Antibacterial Activity and Promoted Regeneration for Treating MRSA-Infected Bone Defects.Advanced healthcare materials · 2025Article
- Article
- Enhanced functionalities of biomaterials through metal ion surface modification.Frontiers in bioengineering and biotechnology · 2025Review
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Injectable citrate-based polyurethane-urea as a tug-of-war-inspired bioactive self-expansive and planar-fixing screw augmented bone-tendon healing.Bioactive materials · 2024Article
- Fabrication and performance of Zinc-based biodegradable metals: From conventional processes to laser powder bed fusion.Bioactive materials · 2024Review
- An adaptive biodegradable zinc alloy with bidirectional regulation of bone homeostasis for treating fractures and aged bone defects.Bioactive materials · 2024Article
- Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair.Stem cell research & therapy · 2024Article
- Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms.Materials today. Bio · 2024Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is no targeted effective treatment for patients undergoing internal fixation surgery/two-stage total joint revision surgery with a high risk of postoperative infection and osteolysis, while the rate of reoperation due to infection and osteolysis remains high. In this study, we report a pioneering application of implants made of biodegradable Zn-Ag alloy with active antibacterial and anti-osteolytic properties in three classical animal models, illustrating antibacterial, anti-osteolysis, and internal fixation for fractures. The antibacterial activity of the Zn-2Ag alloy was verified in a rat femur osteomyelitis prevention model, while the anti-osteolytic properties were evaluated using a mouse cranial osteolysis model. Moreover, the Zn-2Ag based screws showed similar performance in bone fracture fixation compared to the Ti-6Al-4V counterpart. The fracture healed completely after 3 months in the rabbit femoral condyle fracture model. Furthermore, the underlying antibacterial mechanism may include inhibition of biofilm formation, autolysis-related pathways, and antibiotic resistance pathways. Osseointegration mechanisms may include inhibition of osteoclast-associated protein expression, no effect on osteogenic protein expression, and no activation of related inflammatory protein expression. The empirical findings here reveal the great potential of Zn-Ag-based alloys for degradable biomaterials in internal fixation surgery/two-stage total joint revision surgery for patients with a high risk of postoperative infection and osteolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.