Evidence map›Paper›PMID 34095617›Full record

ArticleBioactive materials2021

An enhanced method for nucleic acid detection with CRISPR-Cas12a using phosphorothioate modified primers and optimized gold-nanopaticle strip.

Jiaojiao Gong, Lijuan Kan, Xiuming Zhang, Ying He, Jiaqiang Pan, Liping Zhao, Qianyun Li, Menghao Liu, Jie Tian, Sili Lin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Jiaojiao GongYaneng Biotech, Co., Ltd, Fosun Pharma, Shenzhen 518100, China.
Lijuan KanDepartment of Laboratory Medicine, Luohu District People's Hospital, Shenzhen 518001, China.
Xiuming ZhangDepartment of Laboratory Medicine, Luohu District People's Hospital, Shenzhen 518001, China.
Ying HeDepartment of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
Jiaqiang PanYaneng Biotech, Co., Ltd, Fosun Pharma, Shenzhen 518100, China.
Liping ZhaoDepartment of Laboratory Medicine, Nanning First People's Hospital, Nanning 530022, China.
Qianyun LiDepartment of Neurology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.
Menghao LiuNanobiological Medicine Center, Key Lab of Fuel Cell Technology of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Jie TianYaneng Biotech, Co., Ltd, Fosun Pharma, Shenzhen 518100, China.
Sili LinYaneng Biotech, Co., Ltd, Fosun Pharma, Shenzhen 518100, China.
Zhouyu LuYaneng Biotech, Co., Ltd, Fosun Pharma, Shenzhen 518100, China.
Liang XueYaneng Biotech, Co., Ltd, Fosun Pharma, Shenzhen 518100, China.
Chaojun WangDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Guanghui TangYaneng Biotech, Co., Ltd, Fosun Pharma, Shenzhen 518100, China.
Fosun Pharma (China) · CNShenzhen Luohu People's Hospital · CNFirst Affiliated Hospital Zhejiang University · CNFirst People's Hospital of Nanning · CNSouth China University of Technology · CNSun Yat-sen University · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-Cas12a system has been shown promising for nucleic acid diagnostics due to its rapid, portable and accurate features. However, cleavage of the amplicons and primers by the

Indexed as

CRISPR-Cas12aOnepotVisual detection

Identifiers

PMID34095617
PMCPMC8141609
OpenAlexW3165272373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.