Severe long-term progressive corneal remodeling after bilateral simultaneous prophylactic crosslinking and topography-guided surface ablation with mitomycin.

Juan Carlos Abad, Laura Martinez-Cadavid, Andrea Ocampo-Patiño, Emilio A Torres-Netto, Renato Ambrosio

Open access · goldAbstract readCase Reports

In one paragraph

Article in American journal of ophthalmology case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 53% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Juan Carlos AbadPrivate Practice, Medellín, Colombia.

Laura Martinez-CadavidDepartment of Ophthalmology, Universidad Pontificia Bolivariana, Medellín, Colombia.

Andrea Ocampo-PatiñoDepartment of Ophthalmology, Universidad Pontificia Bolivariana, Medellín, Colombia.

Emilio A Torres-NettoDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Renato AmbrosioFederal University of the State of Rio de Janeiro (UNIRIO), Brazil.

Universidad Pontificia Bolivariana · COMunicipality of Medellín · COUniversidade Federal do Estado do Rio de Janeiro · BRUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To report a case of a 20-year-old woman who developed massive and progressive corneal remodeling in both eyes after bilateral PRK with mitomycin and CXL as an elective refractive procedure for mild keratoconus. The patient had 6 years of follow up, initially presenting with focal steepening of up to 20 diopters on both eyes one-and-a-half- years postoperatively that spontaneously reversed over the next five years while the high order aberrations worsened. At the present time, the patient depends on bilateral scleral contact lenses for her day-to-day activities. The use of combined elective PRK with mitomycin and prophylactic CXL could lead to progressive corneal deformation. Additional reports would help to establish the role of this combination procedure among the armamentarium to visually rehabilitate patients with keratoconus.

Indexed as

Athens protocolCorneal crosslinking (CXL)Corneal scarringKeratoconusMitomycin C (MMC)Photorefractive keratectomy (PRK)

Identifiers

PMID34095607

DOI10.1016/j.ajoc.2021.101120

PMCPMC8167240

OpenAlexW3165263926

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.