Evidence map›Paper›PMID 34095604›Full record

ArticleContemporary clinical trials communications2021

Effect of a storytelling intervention on the retention of serodiscordant couples in ART/PrEP services at antenatal clinic in Namacurra province in Zambézia, Mozambique.

Carolyn M Audet, Erin Graves, Almiro M Emílio, Ariano Matino, Paula Paulo, Arifo M Aboobacar, Carlota L Fonseca, Sara Van Rompaey, Caroline De Schacht

Abstract read
In one paragraph

Article in Contemporary clinical trials communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolyn M AudetVanderbilt University Medical Center, Vanderbilt Institute for Global Health, 2525 West End Ave, Suite 750, Nashville, TN, 37203, USA.
Erin GravesVanderbilt University Medical Center, Vanderbilt Institute for Global Health, 2525 West End Ave, Suite 750, Nashville, TN, 37203, USA.
Almiro M EmílioFriends in Global Health, Avenida dos Trabalhadores, 424, Quelimane, Mozambique.
Ariano MatinoFriends in Global Health, Avenida dos Trabalhadores, 424, Quelimane, Mozambique.
Paula PauloFriends in Global Health, Avenida dos Trabalhadores, 424, Quelimane, Mozambique.
Arifo M AboobacarProvincial Health Directorate, Ministry of Health, Province of Zambézia, Quelimane, Mozambique.
Carlota L FonsecaFriends in Global Health, Avenida da Maguiguana, 32 R/C, Maputo, Mozambique.
Sara Van RompaeyFriends in Global Health, Avenida da Maguiguana, 32 R/C, Maputo, Mozambique.
Caroline De SchachtFriends in Global Health, Avenida da Maguiguana, 32 R/C, Maputo, Mozambique.

Funding

Partners-based HIV Treatment for Sero-concordant Couples attending Antenatal Care: Increasing family-based support for PrEP adherence among discordant couples through storytellingR01MH113478 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUDET, CAROLYN · 2017 to 2021
$3.2M
NIMH NIH HHS R01 MH113478
6 · The paper itself

Abstract

backgroundSub-Saharan Africa reported 550,000 new HIV infections among women in 2018. Pregnancy and the postpartum period are associated with an increased risk of HIV acquisition (adjusted risk ratio [RR]: 2.8 during pregnancy and 4.0 in postpartum period vs. non-pregnant or postpartum women, respectively). Acquisition of HIV during pregnancy and breastfeeding increases risk of mother to child transmission. We propose to test the impact of a peer-delivered oral storytelling intervention to increase retention in, and adherence to, pre-exposure prophylaxis (PrEP)/combination antiretroviral treatment (ART) among expectant couples.

designWe propose a randomized controlled trial (RCT) (35 intervention and 35 control couples) at a health facility where 11% of expectant couples were in serodiscordant relationships in 2018. Couples randomized to the storytelling arm will be visited by a two community volunteers and who successfully adhered to PrEP/ART during a recent pregnancy. This expert couple will orate to participating couples three stories (at 1, 3 and 5 weeks after study enrollment) designed to empower, educate, and establish "ideal" interpersonal communication strategies within couples/families, and support adherence practices among participants. The primary outcome among HIV-uninfected women will be adherence to PrEP at 3 months.

conclusionsPrEP among at-risk pregnant women must be implemented so that high levels of adherence and retention are achievable for them and their partners. We will test our storytelling intervention to identify an optimal strategy for PrEP education and family engagement in a region with high HIV prevalence. Our results will have an impact by effectively engaging serodiscordant couples in prevention/treatment during pregnancy and beyond.

Indexed as

Antenatal careMale-engagementMother-to-child transmission of HIVPrEP uptake and adherenceStorytelling

Identifiers

PMID34095604
PMCPMC8167234

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.