ArticleNeurobiology of stress2021
Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Na
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 17 citations in OpenAlex.
- Glucocorticoid receptors in oligodendrocyte precursor cells regulate hippocampal network plasticity and stress-induced behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse.Molecular psychiatry · 2026Article
- Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity.eNeuro · 2025Article
- Probing the roles of developmentally active neurons, in early-life adversity induced disruptions of adult behaviors.Frontiers in neuroscience · 2025Review
- Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice.Biology of sex differences · 2024Article
- NG2-glia: rising stars in stress-related mental disorders?Molecular psychiatry · 2023Article
- Effects of chronic social stress on oligodendrocyte proliferation-maturation and myelin status in prefrontal cortex and amygdala in adult mice.Neurobiology of stress · 2022Article
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Authors and funding
15 authors at 4 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. First, we have established a link between maternal behavior, activation of the offspring's stress response and heterogeneity in the outcome to LBN manipulation. We further showed that LBN targets the hippocampal NG2+ transcriptome with glucocorticoids being an important mediator of the LBN-induced molecular changes. LBN altered the NG2+ transcriptome and these transcriptional effects were correlated with glucocorticoids levels. The functional relevance of one LBN-induced candidate gene,
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