Evidence map›Paper›PMID 34095359›Full record

ArticleCurrent opinion in behavioral sciences2021

Improving precision functional mapping routines with multi-echo fMRI.

Charles J Lynch, Immanuel Elbau, Conor Liston

Abstract read
In one paragraph

Article in Current opinion in behavioral sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Article
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  10. Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  17. The promise of precision functional mapping for neuroimaging in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Charles J LynchDepartment of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, 413 East 69 Street, Box 240, New York, NY 10021.
Immanuel ElbauDepartment of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, 413 East 69 Street, Box 240, New York, NY 10021.
Conor ListonDepartment of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine, 413 East 69 Street, Box 240, New York, NY 10021.

Funding

Targeting salience network dysfunction in depression with individualized brain network mapping and TMSF32MH120989 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LYNCH, CHARLES JOSEPH · 2019 to 2021
$194k
NIMH NIH HHS F32 MH120989
6 · The paper itself

Abstract

Rapidly developing approaches to acquiring and analyzing densely-sampled, single-subject fMRI data have opened new avenues for understanding the neurobiological basis of individual differences in behavior and could allow fMRI to become a more clinically useful tool. Here, we review briefly key insights from these precision functional mapping studies and a highlight significant barrier to their clinical translation. Specifically, that reliable delineation of functional brain networks in individual humans can require hours of resting-state fMRI data per-subject. We found recently that multi-echo fMRI improves the test-retest reliability of resting-state functional connectivity measurements, mitigating the need for acquiring large quantities of per -subject data. Because the benefits of multi-echo acquisitions are most pronounced in clinically important but artifact-prone brain regions, such as the subgenual cingulate and structures deep in the subcortex, this approach has the potential to increase the impact of precision functional mapping routines in both healthy and clinical populations.

Indexed as

functional brain networksmulti-echo fMRIPrecision functional mappingtest-retest reliability

Identifiers

PMID34095359
PMCPMC8174781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.