ArticleBioMed research international2021
Prognostic Value of Blood Urea Nitrogen/Creatinine Ratio for Septic Shock: An Analysis of the MIMIC-III Clinical Database.
Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 38 citations in OpenAlex.
- Systemic immune-inflammation (SII) index as a novel prognostic biomarker in critically ill patients with sepsis: analysis of the MIMIC-IV cohort and predictive modeling based on machine learning.BMC infectious diseases · 2026Article
- Development and evaluation of predictive performance of "organ failure assessment by ratio score" to predict sepsis mortality in Indian intensive care unit patients: An observational study.Indian journal of anaesthesia · 2026Article
- The correlation between blood urea nitrogen to creatinine ratio and short-term and long-term all-cause mortality in sepsis-associated acute kidney injury patients aged 50 and above: a large retrospective cohort study.Frontiers in endocrinology · 2026Article
- Development and validation of an explainable XGBoost model for early mortality prediction in pediatric sepsis.Frontiers in pediatrics · 2026Article
- Association between blood urea nitrogen-to-creatinine ratio and mortality risk in critically ill patients with ventilator-associated pneumonia: a retrospective study.Frontiers in medicine · 2026Article
- Dyskalaemia as a predictor of mortality in sepsis: a retrospective cohort study.BMC infectious diseases · 2025Article
- Survival analysis for sepsis patients: A machine learning approach to feature selection and predictive modeling.Scientific reports · 2025Article
- Parenclitic network mapping predicts survival in critically ill patients with sepsis.Physiological reports · 2025Article
- Interaction between age and blood urea nitrogen to creatinine ratio on mortality in patients with severe cirrhosis: a retrospective cohort study from the MIMIC database.Frontiers in endocrinology · 2025Article
- A prediction for sepsis in adult patients with severe cerebrovascular disease from neurological intensive care unit.Frontiers in neurology · 2025Article
- Targeting serum phosphate trajectory stratification to improve outcomes in high-risk Cardiovascular-Kidney-Metabolic-Sepsis cohorts.PloS one · 2025Article
- Expression of Serum LMAN2 and Sestrin2 in Septic Shock Patients and Exploration of Their Prognostic Value.Journal of inflammation research · 2025Article
- Article
- Blood urea nitrogen to creatinine ratio is associated with in-hospital mortality in critically ill patients with venous thromboembolism: a retrospective cohort study.Frontiers in cardiovascular medicine · 2024Article
- Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database.Scientific reports · 2023Article
- Article
- Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis.Infectious diseases and therapy · 2023Article
- A predictive model for prognosis in very low birth weight infants with late-onset sepsis.Pediatric research · 2023Article
- Development of a nomogram for predicting 90-day mortality in patients with sepsis-associated liver injury.Scientific reports · 2023Article
- The predictive values of admission characteristics for 28-day all-cause mortality in septic patients with diabetes mellitus: a study from the MIMIC database.Frontiers in endocrinology · 2023Article
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9 authors at 2 institutions in 1 country.
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Abstract
backgroundResearch has previously been done into the risk factors for mortality in septic shock patients. However, there has been no epidemiological study investigating the effect of the blood urea nitrogen/creatinine ratio (BCR) on the prognosis of critically ill septic shock patients. This study is aimed at determining the relationship between BCR and all-cause mortality in adult septic shock patients.
methodsData were extracted from the MIMIC-III database. The clinical endpoints were 28-, 90-, and 365-day all-cause mortality rates in critically ill septic shock patients. Cox proportional hazards models and subgroup analyses were used to analyze the relationship between BCR quartiles and all-cause mortality in septic shock patients. Receiver operator characteristic (ROC) curves and areas under the ROC curves (AUCs) were calculated to evaluate how accurately BCR predicts the mortality of septic shock patients.
resultsAmong the 2484 septic shock patients extracted from the database, 619, 563, 677, and 625 fell into the first (<14.4 mg/dL), second (≥14.4 mg/dL and <20.0 mg/dL), third (≥20.0 mg/dL and <27.3 mg/dL), and fourth (≥27.3 mg/dL) quartiles of BCR, respectively. Male and white patients accounted for 53.8% (1336 patients) and 74.8% (1857 patients) of the population, respectively. The mean age of the population was 67.7 ± 15.8 years. An inverse M-shaped relationship between BCR and mortality in septic shock patients was identified, with a value of ≥27.3 mg/dL providing the highest risk (HR = 1.596, 95% CI: 1.396-1.824,
conclusionAn inverse M-shaped curve was determined between BCR and the mortality of septic shock patients. BCR was identified as a readily available and independent prognostic biomarker for septic shock patients, and higher BCRs were associated with increased mortality in these patients.
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