Evidence map›Paper›PMID 34095219›Full record

ArticleFrontiers in molecular biosciences2021

Comparison of Immediate and Sequential Withdrawal of a Systemic Glucocorticoid in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Parallel-Controlled, Open-Label Study.

Ling Zhou, Yuanyuan Fang, Wei Liu, Jianchu Zhang, Yingnan Wang, Sheng Xie, Minhua Zhong, Zhengyan Wang, Guangcai Li, Hongyan Ai and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 16 institutions in 1 country.

Ling ZhouDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuanyuan FangDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wei LiuDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Jianchu ZhangDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yingnan WangDepartment of Respiratory and Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang, Yichang, China.
Sheng XieDepartment of Respiratory and Critical Care Medicine, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.
Minhua ZhongDepartment of Respiratory and Critical Care Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, China.
Zhengyan WangDepartment of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, China.
Guangcai LiDepartment of Respiratory and Critical Care Medicine, The Central Hospital of Enshi Tujia and Miao Autonmous Prefecture, Enshi Clinical College of Wuhan University, Enshi Tujia and Miao Autonomous Prefecture, Hubei, China.
Hongyan AiDepartment of Respiratory and Critical Care Medicine, Hanyang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
Hongrong GuoDepartment of Respiratory and Critical Care Medicine, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China.
Fanjun ZengDepartment of Respiratory and Critical Care Medicine, The First College of Clinical Medicine Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, China.
Wei XiaoDepartment of Respiratory and Critical Care Medicine, The First People's Hospital of Jingzhou, Jingzhou, China.
Chenghong LiDepartment of Respiratory and Critical Care Medicine, The Sixth Hospital of Wuhan, Jianghan University, Wuhan, China.
Yi HuDepartment of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yijun TangDepartment of Respiratory and Critical Medical, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan, China.
Huiguo LiuDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huazhong University of Science and Technology · CNCentral Hospital of Wuhan · CNChina Three Gorges University · CNFirst People's Hospital of Jingzhou · CNHuangshi Central Hospital · CNHubei University of Medicine · CNTaihe Hospital · CNThe Central Hospital of Enshi Tujia and Miao Autonomous Prefecture · CNThe Central Hospital of Xiao gan · CNTongji Hospital · CNUnion Hospital · CNWuhan Sixth Hospital · CNWuhan Third Hospital · CNWuhan University · CNWuhan University of Science and Technology · CNYichang Central People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) were treated with immediate or sequential withdrawal after 5 days of systemic glucocorticoids. The effects of the two withdrawal methods on the prognosis of patients were compared at 30, 90, 180, and 360 days after discharge. A multicenter, randomized, double-blind, parallel-controlled, open-label study was conducted in the respiratory department of tertiary hospitals in Central China. Patients met inclusion criteria for AECOPD and needed to use systemic glucocorticoids. They were randomly assigned to immediate and sequential withdrawal groups at a 1:1 ratio. The study was completed in August 2020 and is registered at the China Clinical Trials Registry (Chictr.org) (ChiCTR1800018894). According to general data and clinical characteristics, there were no statistically significant differences between the 329 patients in the immediate withdrawal group and the 310 patients in the sequential withdrawal group (

Indexed as

acute exacerbations of chronic obstructive pulmonary diseaseCentral Chinaglucocorticoidsimmediately withdrawalmethyl predroneprognosissequential withdrawal

Identifiers

PMID34095219
PMCPMC8173198
OpenAlexW3161862651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.