ReviewFrontiers in cell and developmental biology2021
Understanding Reproductive Aging in Wildlife to Improve Animal Conservation and Human Reproductive Health.
Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Acute exposure to diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP) impacts pituitary hormones and inflammatory markers, suggesting altered reproductive aging in adult female mice.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Dictyota dichotoma extract as a potential nutraceutical for male fertility: insights into semen quality, testicular histology, immunomodulation, and anti-inflammatory markers in rabbit bucks.BMC veterinary research · 2026Article
- Wild Bird Reproduction: Neuroendocrinology, Conservation Biology, and Environmental Threats.Advances in experimental medicine and biology · 2026Review
- The role of genetic variation in shaping phenotypic responses to diet in aging Drosophila melanogaster.Heredity · 2025Article
- Genome instability in mammalian embryos implications for genome editing, development, and evolution.Current opinion in genetics & development · 2025Review
- Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage.Life science alliance · 2025Article
- Germ cells and the aging niche: a systems approach to reproductive longevity.Journal of assisted reproduction and genetics · 2025Review
- Bridging studies in wild animal species and humans to better understand, assist, and control reproduction.F&S reports · 2025Article
- Enhancing genetic management in captive Asian elephants: Evaluation of mitochondrial single-nucleotide polymorphism markers for improved breeding and conservation in the Elephant Kingdom, Thailand.Veterinary world · 2025Article
- A review of antioxidant strategies to improve reproduction in aging male broiler breeders.GeroScience · 2025Review
- X*Y females exhibit steeper reproductive senescence in the African pygmy mouse.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Male aging in germ cells: What are we inheriting?Genetics and molecular biology · 2025Article
- Aging leads to sex-dependent effects on pair bonding and increased number of oxytocin-producing neurons in monogamous prairie voles.Hormones and behavior · 2024Article
- Reproduction results in parallel changes of oxidative stress and immunocompetence in a wild long-living mammal-edible dormouseBiology letters · 2024Article
- Global challenges in aging: insights from comparative biology and one health.Frontiers in toxicology · 2024Review
- Age-specific reproduction in female Steller sea lions in Southeast Alaska.Ecology and evolution · 2023Article
- Development of a quantitative fluorescence lateral flow immunoassay (LFIA) prototype for point-of-need detection of anti-Müllerian hormone.Practical laboratory medicine · 2023Article
- Article
- Editorial: Healthspan and neural aging: Merging the exposome and one environmental health - From molecular mechanisms to epidemiology.Frontiers in aging neuroscience · 2023Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Similar to humans and laboratory animals, reproductive aging is observed in wild species-from small invertebrates to large mammals. Aging issues are also prevalent in rare and endangered species under human care as their life expectancy is longer than in the wild. The objectives of this review are to (1) present conserved as well as distinctive traits of reproductive aging in different wild animal species (2) highlight the value of comparative studies to address aging issues in conservation breeding as well as in human reproductive medicine, and (3) suggest next steps forward in that research area. From social insects to mega-vertebrates, reproductive aging studies as well as observations in the wild or in breeding centers often remain at the physiological or organismal scale (senescence) rather than at the germ cell level. Overall, multiple traits are conserved across very different species (depletion of the ovarian reserve or no decline in testicular functions), but unique features also exist (endless reproductive life or unaltered quality of germ cells). There is a broad consensus about the need to fill research gaps because many cellular and molecular processes during reproductive aging remain undescribed. More research in male aging is particularly needed across all species. Furthermore, studies on reproductive aging of target species in their natural habitat (sentinel species) are crucial to define more accurate reproductive indicators relevant to other species, including humans, sharing the same environment. Wild species can significantly contribute to our general knowledge of a crucial phenomenon and provide new approaches to extend the reproductive lifespan.
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Registered trials
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