Evidence map›Paper›PMID 34095114›Full record

ArticleFrontiers in cell and developmental biology2021

Reduced Expression of GABA

Selma Staege, Anna Kutschenko, Hauke Baumann, Hannes Glaß, Lisa Henkel, Thomas Gschwendtberger, Norman Kalmbach, Martin Klietz, Andreas Hermann, Katja Lohmann and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. [Effects ofZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Selma StaegeDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Anna KutschenkoDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Hauke BaumannInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Hannes GlaßTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University of Rostock, Rostock, Germany.
Lisa HenkelDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Thomas GschwendtbergerDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Norman KalmbachDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Martin KlietzDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Andreas HermannTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University of Rostock, Rostock, Germany.
Katja LohmannInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Philip SeiblerInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Florian WegnerDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Medizinische Hochschule Hannover · DEUniversity of Lübeck · DEGerman Center for Neurodegenerative Diseases · DEUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DYT-THAP1 dystonia (formerly DYT6) is an adolescent-onset dystonia characterized by involuntary muscle contractions usually involving the upper body. It is caused by mutations in the gene

Indexed as

calcium dynamicsDYT-THAP1GABAA receptorgenetic dystoniainduced pluripotent stem cellspatch-clamp electrophysiologystriatal medium spiny neurons

Identifiers

PMID34095114
PMCPMC8176025
OpenAlexW3160413565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.