ArticleCanadian journal of gastroenterology & hepatology2021
Frailty in Nonalcoholic Fatty Liver Cirrhosis: A Comparison with Alcoholic Cirrhosis, Risk Patterns, and Impact on Prognosis.
Article in Canadian journal of gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- A systematic review of the relationship between body composition including muscle, fat, bone, and body water and frailty in Asian residents.Nagoya journal of medical science · 2025Pooled it
- Frailty and transplant-free survival of patients with liver cirrhosis: A meta-analysis.PloS one · 2024Pooled it
- Frailty as a determinant of liver transplant outcomes: A call for integrative strategies.World journal of transplantation · 2025Article
- Article
- Assessment of intestinal inflammation via fecal calprotectin for early prediction of adverse outcomes in advanced chronic liver disease.United European gastroenterology journal · 2025Article
- Prospective study on time-to-tertiary care in alcohol-associated hepatitis: space-time coordinates as prognostic tool and therapeutic target.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Observational
- Article
- Role of Nutrition in the Management of Chronic Liver Disease.Gastro hep advances · 2025Review
- The impact of dietary fiber on colorectal cancer patients based on machine learning.Frontiers in nutrition · 2025Article
- 3PM-guided innovation in treatments of severe alcohol-associated hepatitis utilizing fecal microbiota transplantation.The EPMA journal · 2024Article
- Systemic treatment of hepatocellular carcinoma secondary to non-alcoholic fatty liver disease.World journal of clinical oncology · 2024Review
- Etiology-Specific Effects of Impaired Functional Status on Liver Transplant Outcomes.Digestive diseases and sciences · 2024Article
- Outcomes in Cirrhosis-Related Refractory Ascites with Emphasis on Palliative Care: Single-Centre Experience and Literature Review.Current hepatology reports · 2024Article
- Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide, and Glucagon Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Medication in New Liver Disease Nomenclature.International journal of molecular sciences · 2024Review
- The prevalence and characteristics of frailty in cirrhosis patients: a meta-analysis and systematic review.Frontiers in medicine · 2024Article
- Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017-2020.Frontiers in public health · 2024Article
- Frailty in end-stage liver disease: Understanding pathophysiology, tools for assessment, and strategies for management.World journal of gastroenterology · 2023Review
- Establishing a HOPE Program in a Real-life Setting: A Brazilian Case Series.Transplantation direct · 2023Article
- Frailty as a predictor of poor outcomes among patients awaiting liver transplant: a systematic review and meta-analysis.Gastroenterology and hepatology from bed to bench · 2023Review
- Prevalence of frailty in patients with non-cirrhotic non-alcoholic fatty liver disease.BMJ open gastroenterology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Physical frailty increases susceptibility to stressors and predicts adverse outcomes of cirrhosis. Data on disease course in different etiologies are scarce, so we aimed to compare the prevalence and risk factors of frailty and its impact on prognosis in nonalcoholic fatty liver (NAFLD) and alcoholic (ALD) cirrhosis. Results: Patients with NAFLD compared with ALD were older and had a higher proportion of females, higher body mass index (BMI) and mid-arm circumference (MAC), lower MELD score, CRP, and lower proportion of refractory ascites. The liver frailty index did not differ, and the prevalence of HCC was higher (17.1 vs. 6.8%, Conclusion: Patients with NAFLD cirrhosis had a comparable prevalence of frailty compared to ALD. Although prognostic indices showed less advanced disease, NAFLD patients were more sensitive to frailty, which reflected their higher overall disease burden and led to higher all-cause mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.