Evidence map›Paper›PMID 34095009›Full record

ReviewJournal of lipid and atherosclerosis2021

Zebrafish Vascular Development: General and Tissue-Specific Regulation.

Hiroyuki Nakajima, Ayano Chiba, Moe Fukumoto, Nanami Morooka, Naoki Mochizuki

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of lipid and atherosclerosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Toxics · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Small Fish, Big Answers: Zebrafish and the Molecular Drivers of Metastasis.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Science advances · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Frontiers in cell and developmental biology · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hiroyuki NakajimaDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.ORCID https://orcid.org/0000-0003-4139-2779
Ayano ChibaDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.ORCID https://orcid.org/0000-0003-2536-2449
Moe FukumotoDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.ORCID https://orcid.org/0000-0001-8081-1353
Nanami MorookaDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.ORCID https://orcid.org/0000-0002-7223-8398
Naoki MochizukiDepartment of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.ORCID https://orcid.org/0000-0002-3938-9602
National Cerebral and Cardiovascular Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulation is required for the delivery of oxygen and nutrition to tissues and organs, as well as waste collection. Therefore, the heart and vessels develop first during embryogenesis. The circulatory system consists of the heart, blood vessels, and blood cells, which originate from the mesoderm. The gene expression pattern required for blood vessel development is predetermined by the hierarchical and sequential regulation of genes for the differentiation of mesodermal cells. Herein, we review how blood vessels form distinctly in different tissues or organs of zebrafish and how vessel formation is universally or tissue-specifically regulated by signal transduction pathways and blood flow. In addition, the unsolved issues of mutual contacts and interplay of circulatory organs during embryogenesis are discussed.

Indexed as

3-D imagingEndothelial cellSignal transductionZebrafish

Identifiers

PMID34095009
PMCPMC8159758
OpenAlexW3134005334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.