Evidence map›Paper›PMID 34094999›Full record

ArticleFrontiers in cellular and infection microbiology2021

Erin Trent Malone, Sean Ganther, Nevina Mena, Allan Radaic, Keemia Shariati, Abigail Kindberg, Christian Tafolla, Pachiyappan Kamarajan, J Christopher Fenno, Ling Zhan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Immunostimulatory effects ofInfection and immunity · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Periodontal Disease: The Good, The Bad, and The Unknown.Frontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Erin Trent MaloneKapila Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
Sean GantherKapila Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
Nevina MenaKapila Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
Allan RadaicKapila Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
Keemia ShariatiKapila Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
Abigail KindbergBush Laboratory, Department of Cell and Tissue Biology, Biomedical Sciences Graduate, University of California San Francisco, San Francisco, CA, United States.
Christian TafollaKapila Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
Pachiyappan KamarajanKapila Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
J Christopher FennoFenno Laboratory, Department of Biological and Material Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.
Ling ZhanZhan Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
Yvonne L KapilaKapila Laboratory, Department of Orofacial Sciences, School of Dentistry San Francisco, University of California San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USUniversity of San Francisco · USMaterial Sciences (United States) · US

Funding

Treponema - Host Cell and Tissue InteractionsR01DE025225 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI J CHRISTOPHER FENNO, Yvonne L Kapila · 2015 to 2026
$6.3M
Characterization of Treponema Denticola-Mediated Interactions With Periodontal Ligament Cells Leading to Persistent Host Cell/Tissue DestructionF30DE027598 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALONE, ERIN TRENT · 2017 to 2022
$280k
NIDCR NIH HHS F30 DE027598
6 · The paper itself

Abstract

The periodontal complex consists of the periodontal ligament (PDL), alveolar bone, and cementum, which work together to turn mechanical load into biological responses that are responsible for maintaining a homeostatic environment. However oral microbes, under conditions of dysbiosis, may challenge the actin dynamic properties of the PDL in the context of periodontal disease. To study this process, we examined host-microbial interactions in the context of the periodontium

Indexed as

Matrix Metalloproteinase 2Treponema denticolaFibroblastsHumansras GTPase-Activating ProteinsTranscriptional ActivationUp-RegulationMatrix Metalloproteinase 2MMP2 protein, humanRASA4 protein, humanras GTPase-Activating Proteinsactin reorganizationmatrix mettaloproteinase-2periodontal ligament (PDL)RASA4Treponema denticola

Identifiers

PMID34094999
PMCPMC8171266
OpenAlexW3162700156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.