Evidence map›Paper›PMID 34094994›Full record

ArticleFrontiers in cellular and infection microbiology2021

The Vaginal Microbial Signatures of Preterm Birth Delivery in Indian Women.

Shakti Kumar, Naina Kumari, Daizee Talukdar, Akansha Kothidar, Mousumi Sarkar, Ojasvi Mehta, Pallavi Kshetrapal, Nitya Wadhwa, Ramachandran Thiruvengadam, Bapu Koundinya Desiraju and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Contribution ofFrontiers in cellular and infection microbiology · 2021
    Pooled it
  2. Trial
  3. Article
  4. Vaginal Microbiome and Preterm Birth in Pregnant Women From India.The journal of obstetrics and gynaecology research · 2026
    Article
  5. Article
  6. Vaginal microbiome and its implications in preterm birth.Obstetrics & gynecology science · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Shakti KumarMolecular Genetics Laboratory, Translational Health Science and Technology Institute, National Capital Region (NCR) Biotech Science Cluster, Faridabad, India.
Naina KumariNational Institute of Biomedical Genomics, Kalyani, India.
Daizee TalukdarMolecular Genetics Laboratory, Translational Health Science and Technology Institute, National Capital Region (NCR) Biotech Science Cluster, Faridabad, India.
Akansha KothidarMolecular Genetics Laboratory, Translational Health Science and Technology Institute, National Capital Region (NCR) Biotech Science Cluster, Faridabad, India.
Mousumi SarkarNational Institute of Biomedical Genomics, Kalyani, India.
Ojasvi MehtaMolecular Genetics Laboratory, Translational Health Science and Technology Institute, National Capital Region (NCR) Biotech Science Cluster, Faridabad, India.
Pallavi KshetrapalPediatric Biology Center, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
Nitya WadhwaPediatric Biology Center, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
Ramachandran ThiruvengadamPediatric Biology Center, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
Bapu Koundinya DesirajuPediatric Biology Center, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
G Balakrish NairMolecular Genetics Laboratory, Translational Health Science and Technology Institute, National Capital Region (NCR) Biotech Science Cluster, Faridabad, India.
Shinjini BhatnagarPediatric Biology Center, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
Souvik MukherjeeNational Institute of Biomedical Genomics, Kalyani, India.
Bhabatosh DasMolecular Genetics Laboratory, Translational Health Science and Technology Institute, National Capital Region (NCR) Biotech Science Cluster, Faridabad, India.
GARBH-Ini Study Group
Translational Health Science and Technology Institute · INNational Institute of Biomedical Genomics · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The incidence of preterm birth (PTB) in India is around 13%. Specific bacterial communities or individual taxon living in the vaginal milieu of pregnant women is a potential risk factor for PTB and may play an important role in its pathophysiology. Besides, bacterial taxa associated with PTB vary across populations. Objective: Conduct a comparative analysis of vaginal microbiome composition and microbial genomic repertoires of women who enrolled in the Interdisciplinary Group for Advanced Research on Birth Outcomes - A DBT India Initiative (GARBH-Ini) pregnancy cohort to identify bacterial taxa associated with term birth (TB) and PTB in Indian women. Methods: Vaginal swabs were collected during all three trimesters from 38 pregnant Indian women who delivered spontaneous term (n=20) and preterm (n=18) neonates. Paired-end sequencing of V3-V4 region of 16S rRNA gene was performed using the metagenomic DNA isolated from vaginal swabs (n=115). Whole genome sequencing of bacterial species associated with birth outcomes was carried out by shotgun method. Results: Vaginal microbiome of both term and preterm samples reveals similar alpha diversity indices. However, significantly higher abundance of Conclusion: Our findings indicate that the dominance of specific

Indexed as

Premature BirthFemaleFusobacteriaHumansIndiaInfant, NewbornLactobacillusPregnancyRNA, Ribosomal, 16SVaginaRNA, Ribosomal, 16S16S rRNA gene sequencingLactobacillusmicrobial ecologypreterm birthvaginal microbiota

Identifiers

PMID34094994
PMCPMC8169982
OpenAlexW3160235274

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.