Evidence map›Paper›PMID 34094956›Full record

ArticleFrontiers in oncology2021

Feasibility of Different Tumor Delineation Approaches for

Lena M Mittlmeier, Matthias Brendel, Leonie Beyer, Nathalie L Albert, Andrei Todica, Mathias J Zacherl, Vera Wenter, Annika Herlemann, Alexander Kretschmer, Stephan T Ledderose and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

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  12. Multimodal integration of [Frontiers in oncology · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Evaluation of thresholding methods for the quantification of [European journal of nuclear medicine and molecular imaging · 2023
    Article
  18. Article
  19. Total Tumor Volume onBiomedicines · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Lena M MittlmeierDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Leonie BeyerDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Nathalie L AlbertDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Andrei TodicaDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Mathias J ZacherlDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Vera WenterDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Annika HerlemannDepartment of Urology, University Hospital, LMU Munich, Munich, Germany.
Alexander KretschmerDepartment of Urology, University Hospital, LMU Munich, Munich, Germany.
Stephan T LedderoseDepartment of Pathology, University Hospital, LMU Munich, Munich, Germany.
Nina-Sophie Schmidt-HegemannDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.
Wolfgang G KunzDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Jens RickeDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Harun IlhanDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Marcus UnterrainerDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DELMU Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelineation of PSMA-positive tumor volume on PET using PSMA-ligands is of highest clinical interest as changes of PSMA-PET/CT-derived whole tumor volume (WTV) have shown to correlate with treatment response in metastatic prostate cancer patients. So far, WTV estimation was performed on PET using

methodsFifty patients with metastatic prostate cancer,

resultsA fixed SUV of 4.0 (r=0.807, r

conclusionsA threshold of SUV 4.0 for tumor delineation showed highest association with volumetric reference standard irrespective of potential changes in PSMA-avidity of background tissues (e. g. parotis). This approach is easily applicable in clinical routine without specific software requirements. Further studies applying this approach for total tumor volume delineation are initiated.

Indexed as

mCRPCMetastatic castrate-resistant prostate cancerPETprostate cancerPSMAwhole tumor volume

Identifiers

PMID34094956
PMCPMC8176856
OpenAlexW3165104578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.