Evidence map›Paper›PMID 34094913›Full record

ReviewFrontiers in oncology2021

Beyond Conventional: The New Horizon of Targeted Therapy for the Treatment of Advanced Non Small Cell Lung Cancer.

Alfredo Tartarone, Vittoria Lapadula, Concetta Di Micco, Gemma Rossi, Carlotta Ottanelli, Andrea Marini, Roberta Giorgione, Katia Ferrari, Martina Catalano, Luca Voltolini and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Assessing the prognostic value ofFrontiers in oncology · 2024
    Article
  4. Immunomodulatory role of EV-derived non-coding RNA in lung cancer.Extracellular vesicles and circulating nucleic acids · 2023
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Alfredo TartaroneDepartment of Onco-Hematology, Division of Medical Oncology IRCCS-CROB Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
Vittoria LapadulaDepartment of Onco-Hematology, Division of Medical Oncology IRCCS-CROB Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
Concetta Di MiccoDivision of Medical Oncology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Gemma RossiSchool of Human Health Sciences, University of Florence, Florence, Italy.
Carlotta OttanelliSchool of Human Health Sciences, University of Florence, Florence, Italy.
Andrea MariniSchool of Human Health Sciences, University of Florence, Florence, Italy.
Roberta GiorgioneSchool of Human Health Sciences, University of Florence, Florence, Italy.
Katia FerrariRespiratory Medicine, Careggi University Hospital, Florence, Italy.
Martina CatalanoSchool of Human Health Sciences, University of Florence, Florence, Italy.
Luca VoltoliniThoracic Surgery Unit, Careggi University Hospital, Florence, Italy.
Enrico MiniDepartment of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
Giandomenico RovielloDepartment of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · ITCasa Sollievo della Sofferenza · ITCentro di Riferimento Oncologico della Basilicata · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last few years the advent of targeted therapies against oncogenic drivers significantly improved the survival of non small cell lung cancer (NSCLC) patients with a favourable toxicity profile. Therefore, genetic testing, including at least EGFR mutations and ALK/ROS1 rearrangements, should be performed in all NSCLC patients (in particular with adenocarcinoma) who received a diagnosis of advanced disease. This review focuses on novel druggable oncogenic drivers, such as MET exon 14 mutations/MET amplification, RET fusions, BRAF V600E mutations, KRAS G12C mutations, NTRK rearrangements, and HER2 alterations.

Indexed as

genetic testingMETnon small cell lung canceroncogenic driverstargeted therapies

Identifiers

PMID34094913
PMCPMC8176852
OpenAlexW3164644043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.