Evidence map›Paper›PMID 34094909›Full record

ArticleFrontiers in oncology2021

Dysregulation of Transcription Factor Networks Unveils Different Pathways in Human Papillomavirus 16-Positive Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix.

Saloe Bispo, Ticiana D J Farias, Patricia Savio de Araujo-Souza, Ricardo Cintra, Hellen Geremias Dos Santos, Natasha Andressa Nogueira Jorge, Mauro Antônio Alves Castro, Gabriel Wajnberg, Nicole de Miranda Scherer, Maria Luiza Nogueira Dias Genta and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 3 countries.

Saloe BispoInstituto Carlos Chagas, FIOCRUZ, Curitiba, Brazil.
Ticiana D J FariasInstituto Carlos Chagas, FIOCRUZ, Curitiba, Brazil.
Patricia Savio de Araujo-SouzaDepartment of Immunobiology, Biology Institute, Universidade Federal Fluminense (UFF), Niterói, Brazil.
Ricardo CintraDepartment of Biochemistry, Instituto de Quimica, Universidade de São Paulo, São Paulo, Brazil.
Hellen Geremias Dos SantosInstituto Carlos Chagas, FIOCRUZ, Curitiba, Brazil.
Natasha Andressa Nogueira JorgeInstituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
Mauro Antônio Alves CastroBioinformatics and Systems Biology Laboratory, Federal University of Paraná, Curitiba, Brazil.
Gabriel WajnbergInstituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
Nicole de Miranda SchererLaboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
Maria Luiza Nogueira Dias GentaDiscipline of Gynecology, Department of Obstetrics and Gynecology, Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Jesus Paula CarvalhoDiscipline of Gynecology, Department of Obstetrics and Gynecology, Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Luisa Lina VillaDepartment of Radiology and Oncology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Laura SicheroCenter for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo FMUSP HC, São Paulo, Brazil.
Fabio PassettiInstituto Carlos Chagas, FIOCRUZ, Curitiba, Brazil.
Fundação Carlos Chagas · BRInstituto do Câncer do Estado de São Paulo · BRAtlantic Cancer Research Institute · CAFundação Oswaldo Cruz · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRInstituto Nacional do Câncer · BRLeipzig University · DEUniversidade de São Paulo · BRUniversidade Federal do Paraná · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Squamous cell carcinoma (SCC) and adenocarcinoma (ADC) are the most common histological types of cervical cancer (CC). The worse prognosis of ADC cases highlights the need for better molecular characterization regarding differences between these CC types. RNA-Seq analysis of seven SCC and three ADC human papillomavirus 16-positive samples and the comparison with public data from non-tumoral human papillomavirus-negative cervical tissue samples revealed pathways exclusive to each histological type, such as the epithelial maintenance in SCC and the maturity-onset diabetes of the young (MODY) pathway in ADC. The transcriptional regulatory network analysis of cervical SCC samples unveiled a set of six transcription factor (TF) genes with the potential to positively regulate long non-coding RNA genes

Indexed as

cervical adenocarcinomacervical cancercervical squamous cell carcinomalncRNAmiRNA spongeRNA-Seqtranscriptional regulatory network

Identifiers

PMID34094909
PMCPMC8170088
OpenAlexW3160113890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.