ReviewJournal of orthopaedic translation2021
Copper-based biomaterials for bone and cartilage tissue engineering.
Review in Journal of orthopaedic translation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Biogenic Synthesis of Copper Nanoparticles: A Systematic Review of Their Features and Main Applications.Molecules (Basel, Switzerland) · 2023Pooled it
- 3D-printed multifunctional composite scaffolds incorporating copper ions/amoxicillin/hydroxyapatite for synergistic antibacterial and vascularized bone regeneration.Materials today. Bio · 2026Article
- Spatiotemporal Sonodynamic-Nanozymic Therapy for Infected Jawbone Defects.Advanced healthcare materials · 2026Article
- Phytochemical-mediated green synthesis, mechanistic insights integrated with biological evaluation, density functional theory calculations and molecular docking studies of copper oxide nanoparticles.Scientific reports · 2026Article
- Research advances of copper homeostasis and cuproptosis in orthopedic diseases.Cell death discovery · 2026Review
- Harnessing copper-strontium synergy in an injectable composite for multi-pathway bone regeneration.RSC advances · 2026Article
- Activated Carbon Fiber Incorporated with Metal Ions: Characterization and Biological Interactions In Vitro.International journal of molecular sciences · 2026Article
- Curcumin-loaded copper/iron bimetallic nanoparticle-incorporated hydrogel scaffold: a sequential microenvironment reprogramming platform for accelerated chronic wound healing.Journal of nanobiotechnology · 2026Article
- Injectable hydrogels for osteomyelitis treatment induce metabolic reprogramming for protection against reinfection.Nature communications · 2026Article
- A Biomimetic Scaffold for Single-Stage Reconstruction of Load-Bearing Segmental Bone Defects.BME frontiers · 2026Article
- A novel vascularized hydrogel by encapsulation of lyophilized platelet-rich fibrin into gelatin methacryloyl hydrogel for bone regeneration.Journal of materials science. Materials in medicine · 2025Article
- Eco-Friendly Synthesis of Copper Oxide Nanoparticles Using GeraniumPharmaceutics · 2025Article
- Synergistic dual chemophysical FeCu-MOF scaffold with PEMF stimulation drives angiogenic-osteogenic coupling for bone regeneration.Materials today. Bio · 2025Article
- Biological properties of copper: Antibacterial, osteogenesis of biomaterials.Biochemistry and biophysics reports · 2025Review
- Copper-incorporated hydrogels loaded with curcumin microspheres for the repair of bone defects.Materials today. Bio · 2025Article
- Dual-metal-organic framework and gallic acid incorporated 3D-printed scaffolds: Revolutionizing refractory bone defect repair through immune-angiogenic-neurogenic synergy.Materials today. Bio · 2025Article
- Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.Medicine · 2025Article
- Synergistic Angio-Osteogenic Effects of Copper-Releasing 3D Biocomposite Scaffolds: A Step Toward Vascularized Bone Regeneration.Research square · 2025Article
- Research Progress in Medical Biomaterials for Bone Infections.Journal of functional biomaterials · 2025Review
- Treatment of large bone defects in load-bearing bone: traditional and novel bone grafts.Journal of Zhejiang University. Science. B · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroudTissue engineering using cells, scaffolds, and bioactive molecules can promote the repair and regeneration of injured tissues. Copper is an essential element for the human body that is involved in many physiological activities and in recent years, copper has been used increasingly in tissue engineering.
methodsThe current advances of copper-based biomaterial for bone and cartilage tissue engineering were searched on PubMed and Web of Science.
resultsVarious forms of copper-based biomaterials, including pure copper, copper ions, copper nanoparticles, copper oxides, and copper alloy are introduced. The incorporation of copper into base materials provides unique properties, resulting in tuneable porosity, mechanical strength, degradation, and crosslinking of scaffolds. Copper also shows promising biological performance in cell migration, cell adhesion, osteogenesis, chondrogenesis, angiogenesis, and antibacterial activities. In vivo applications of copper for bone and cartilage tissue engineering are discussed.
conclusionThis review focuses on copper's physiochemical and biological effects, and its applications in bone and cartilage tissue engineering. The potential limitations and future perspectives are also discussed. TRANSLATIONAL POTENTIAL OF THIS ARTICLE: This review introduces the recent advances in copper-based biomaterial for bone and cartilage tissue engineering. This revie could guide researchers to apply copper in biomaterials, improving the generation of bone and cartilages, decrease the possibility of infection and shorten the recovery time so as to decrease medical costs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.