ArticleRespiratory medicine case reports2021
Possible role of COVID-19 in the relapse of Klein-Levin Syndrome.
Article in Respiratory medicine case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Persistent sleep symptoms in post-COVID syndrome: a Brazilian prospective clinical study.Arquivos de neuro-psiquiatria · 2025Observational
- New-onset Kleine-Levin syndrome following COVID-19 infection: A case report.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Acute encephalitis induced Kleine-Levin syndrome with episodic vertical gaze dysfunction during hypersomnia episodes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Long-term follow-up of symptom and quality of life changes in patients with narcolepsy during and after the COVID-19 pandemic.Sleep and biological rhythms · 2024Article
- Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports.Frontiers in neurology · 2024Article
- Relapse of Kleine-Levin Syndrome From COVID-19 Vaccine: Causal or Coincidence?Journal of clinical neurology (Seoul, Korea) · 2023Article
- An Update on Kleine-Levin Syndrome.Current sleep medicine reports · 2023Review
- Central hypersomnia and chronic insomnia: expanding the spectrum of sleep disorders in long COVID syndrome - a prospective cohort study.BMC neurology · 2022Article
- COVID-19 Vaccine Could Trigger the Relapse of Secondary Hypersomnia.Nature and science of sleep · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klein-Levin Syndrome (KLS) is an extremely rare neurological disorder which can manifest as recurring spells of sleepiness, cognitive disturbances and behavioral changes. We present a novel case of KLS relapse in the setting of Coronavirus disease-19 (COVID-19). A 36-year-old male who had a known history of KLS since adolescence was admitted with sleepiness and behavioral disturbances. Brain imaging and autoimmune encephalitis work was unremarkable. The patient was diagnosed with a relapse of KLS secondary to COVID-19 based on symptomology and lack of any other precipitating factor. The patient required 8 days of hospitalization and was treated with benzodiazepines due to a history of robust response to lorazepam during a prior episode. The patient progressively improved and was discharged home on lorazepam taper. We report that similar to other neurotropic viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be the culprit in instigating KLS relapse.
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