Evidence map›Paper›PMID 34094672›Full record

ArticleAmerican journal of cancer research2021

GOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy.

Kai Wang, Yanhua Qi, Xu Wang, Yushuai Liu, Min Zhao, Ding Zhou, Yu Zhang, Yan Wang, Rutong Yu, Xiuping Zhou

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Apolipoproteins L involvement in immunity.Journal of human immunity · 2026
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  6. Review
  7. The Janus-faced functions of Apolipoproteins L in membrane dynamics.Cellular and molecular life sciences : CMLS · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. CircularBioengineered · 2022
    Article
  12. Prohibitins: A Key Link between Mitochondria and Nervous System Diseases.Oxidative medicine and cellular longevity · 2022
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kai WangInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Yanhua QiInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Xu WangInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Yushuai LiuInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Min ZhaoInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Ding ZhouInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Yu ZhangInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Yan WangInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Rutong YuInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Xiuping ZhouInstitute of Nervous System Diseases, Xuzhou Medical University Xuzhou, Jiangsu, China.
Xuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the hypoxia and nutrient deficiency microenvironment, malignant glioma exhibits high autophagy activity and autophagy plays a significant role in the occurrence and development of glioma. However, the potential molecular mechanism of autophagy in glioma remains unknown. In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3), a highly conserved protein basically concentrates in the trans-Golgi network, promoted glioma autophagy. Inhibiting autophagy by using chloroquine suppressed the stimulating effect of GOLPH3 on glioma malignant development both

Indexed as

autophagyGliomaGOLPH3PHB2proliferation

Identifiers

PMID34094672
PMCPMC8167689
OpenAlexW3171390548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.