Evidence map›Paper›PMID 34094670›Full record

ArticleAmerican journal of cancer research2021

Laryngeal squamous cell carcinoma cell lines show high tolerance for siRNA-mediated CDK1 knockdown.

Kinga Bednarek, Magdalena Kostrzewska-Poczekaj, Adam Ustaszewski, Joanna Janiszewska, Katarzyna Kiwerska, Julia Paczkowska, Reidar Grenman, Maciej Giefing, Malgorzata Jarmuz-Szymczak

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kinga BednarekInstitute of Human Genetics, Polish Academy of Sciences Poznan, Poland.
Magdalena Kostrzewska-PoczekajInstitute of Human Genetics, Polish Academy of Sciences Poznan, Poland.
Adam UstaszewskiInstitute of Human Genetics, Polish Academy of Sciences Poznan, Poland.
Joanna JaniszewskaInstitute of Human Genetics, Polish Academy of Sciences Poznan, Poland.
Katarzyna KiwerskaInstitute of Human Genetics, Polish Academy of Sciences Poznan, Poland.
Julia PaczkowskaInstitute of Human Genetics, Polish Academy of Sciences Poznan, Poland.
Reidar GrenmanDepartment of Otorhinolaryngology, Head and Neck Surgery, Turku University Central Hospital and Turku University Turku, Finland.
Maciej GiefingInstitute of Human Genetics, Polish Academy of Sciences Poznan, Poland.
Malgorzata Jarmuz-SzymczakInstitute of Human Genetics, Polish Academy of Sciences Poznan, Poland.
Institute of Human Genetics · PLPolish Academy of Sciences · PLPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations of the cell cycle checkpoints lead to uncontrolled cell growth and result in tumorigenesis. One of the genes essential for cell proliferation and cell cycle regulation is

Indexed as

CDK1cell cycle checkpointgene silencinglaryngeal squamous cell carcinoma (LSCC)

Identifiers

PMID34094670
PMCPMC8167681
OpenAlexW3168619162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.