Evidence map›Paper›PMID 34094519›Full record

ArticleClinical kidney journal2021

High prevalence of end-stage renal disease of unknown origin in Aguascalientes Mexico: role of the registry of chronic kidney disease and renal biopsy in its approach and future directions.

Mauricio Gutierrez-Peña, Leslie Zuñiga-Macias, Ricardo Marin-Garcia, Itzel Ovalle-Robles, Andrea L García-Díaz, Mariana J Macías-Guzmán, Angel Delgado-Bentites, Dulce Maria Macías-Diaz, Carlos Alberto Prado-Aguilar, Alejandro Vega de la Rosa and 9 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07405216 (Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Adolescents With Persistent Albuminuria), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07405216 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Adolescents With Persistent Albuminuria: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorCentenario Hospital Miguel HidalgoRan2026 to 2027Enrolled200ConditionsChronic Kidney Disease (Mild to Moderate), Albuminuria, Adolescent, Sodium Glucose Co-Transporter 2 InhibitorsArmsDapagliflozin (10mg Tab), Placebo
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. CKD in Migrants: From Epidemiology to Challenges.Kidney international reports · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. American journal of physiology. Renal physiology · 2024
    Article
  14. Article
  15. Article
  16. Trends in kidney transplantation rate across Europe: study from the ERA Registry.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Mauricio Gutierrez-PeñaAguascalientes Institute of Health Services, Aguascalientes, Mexico.
Leslie Zuñiga-MaciasDepartment of Internal Medicine, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Ricardo Marin-GarciaAguascalientes Institute of Health Services, Aguascalientes, Mexico.
Itzel Ovalle-RoblesDepartment of Internal Medicine, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Andrea L García-DíazDepartment of Internal Medicine, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Mariana J Macías-GuzmánDepartment of Internal Medicine, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Angel Delgado-BentitesAguascalientes Institute of Health Services, Aguascalientes, Mexico.
Dulce Maria Macías-DiazDepartment of Pathology, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Carlos Alberto Prado-AguilarInstituto Mexicano del Seguro Social, Aguascalientes, Mexico.
Alejandro Vega de la RosaInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Gómez Palacio, Mexico.
Rodolfo Delgadillo-CastañedaAguascalientes Institute of Health Services, Aguascalientes, Mexico.
Alfredo Chew-WonDepartment of Internal Medicine, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Rafael Reyes-AcevedoDepartment of Transplantation, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Dulce Maria Reyes-CamposHospital Médica Avanzada Contigo, Aguascalientes, Mexico.
Marco Antonio Martínez-GuevaraInstituto Mexicano del Seguro Social, Aguascalientes, Mexico.
Emanuel A Mendoza-EncisoDepartment of Internal Medicine, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Bernardo Nava-BecerraDepartment of Internal Medicine, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Miguel Angel Piza-JiménezAguascalientes Institute of Health Services, Aguascalientes, Mexico.
José Manuel Arreola GuerraAguascalientes Institute of Health Services, Aguascalientes, Mexico.
Universidad Villasunción · MXMexican Social Security Institute · MXInstitute for Social Security and Services for State Workers · MXAutonomous University of Aguascalientes · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is one of the pathologies with the greatest impact on the public health system. Over the last few decades, the relevance of CKD in Mexico has increased, with associated overwhelming costs for care of renal disease. There are no reliable CKD statistics in Mexico. METHODOLOGY: In June 2018, the government of Aguascalientes called on all Health Institutions to create a state registry of treated end-stage renal disease (ESRD). In the same system, a renal biopsy result registry included all the native kidney biopsies obtained in the state of Aguascalientes since 2012. We herein describe the prevalence, incidence and characteristics of the patients included in the CKD and renal biopsy registry in the state of Aguascalientes.

resultsAs of April 2020, the state has documented 2827 patients on renal replacement therapy (RRT), 1877 on dialysis and 950 that have been transplanted. The prevalence of patients on dialysis is 1326 per million population (p.m.p.), and if transplanted individuals are included, it is 1997 p.m.p. The incidence of treated ESRD in 2019 was 336 p.m.p. (

conclusionsThe prevalence of treated ESRD in the state of Aguascalientes is high. The disease mostly afflicts young people between 20 and 40 years of age, and there is a clear male predominance. In this age group, the main clinical diagnosis is CKD of unknown origin, and the most frequent biopsy diagnosis was FSGS.

Indexed as

chronic kidney diseasechronic kidney disease of unknown originchronic kidney disease registryfocal segmental glomerulosclerosisrenal biopsy registry

Identifiers

PMID34094519
PMCPMC8173605
OpenAlexW3125513064

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.