ArticleChemical science2020
Phenol-like group functionalized graphene quantum dots structurally mimicking natural antioxidants for highly efficient acute kidney injury treatment.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 95 citations in OpenAlex.
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- Construction of PANoptosis-Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug-Induced Nephrotoxicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Surface-cleaned black phosphorus nanosheets chelate iron and rebalance the ferroptosis-immune axis in acute kidney injury.Theranostics · 2026Article
- ROS-responsive cellular vesicles with ferroptosis-targeting siACMSD delivery for acute kidney injury therapy.Theranostics · 2026Article
- Dual-function TA@CaCOJournal of nanobiotechnology · 2025Article
- Dual-Action flavonol carbonized polymer dots spray: Accelerating burn wound recovery through immune responses modulation and EMT induction.Materials today. Bio · 2025Article
- Fuel-propelled nanomotors for acute kidney injury applications.Pharmaceutical science advances · 2024Review
- Recent advances of photoresponsive nanomaterials for diagnosis and treatment of acute kidney injury.Journal of nanobiotechnology · 2024Review
- Carbon Nanomaterials with SOD-like Activity: The Effect of the Ionic Strength.Molecules (Basel, Switzerland) · 2024Article
- Nanomedicine embraces the treatment and prevention of acute kidney injury to chronic kidney disease transition: evidence, challenges, and opportunities.Burns & trauma · 2024Review
- Green carbon dots derived fromFrontiers in immunology · 2024Article
- Mackinawite nanozymes as reactive oxygen species scavengers for acute kidney injury alleviation.Journal of nanobiotechnology · 2023Article
- Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney.Bioactive materials · 2023Review
- Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment.Bioactive materials · 2023Article
- Ultrasmall and highly biocompatible carbon dots derived from natural plant with amelioration against acute kidney injury.Journal of nanobiotechnology · 2023Article
- Recent advances of antioxidant low-dimensional carbon materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2023Review
- Low dimensional nanomaterials for treating acute kidney injury.Journal of nanobiotechnology · 2022Review
- Bioinspired copper single-atom nanozyme as a superoxide dismutase-like antioxidant for sepsis treatment.Exploration (Beijing, China) · 2022Article
- A MXene-derived redox homeostasis regulator perturbs the Nrf2 antioxidant program for reinforced sonodynamic therapy.Chemical science · 2022Article
- Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie.Journal of inflammation research · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a syndrome characterized by rapid loss of renal excretory function with high in-hospital mortality. The excess generation of reactive oxygen species (ROS) in the kidneys during AKI has been considered a major cause of renal failure. Currently available antioxidants for AKI treatment often lack the required antioxidative efficacy or renal accumulation rate. Herein, inspired by the structure of natural phenolic antioxidants, phenol-like group functionalized graphene quantum dots (h-GQDs) with both high ROS scavenging efficacy and renal specificity are constructed for AKI antioxidative therapy. Similar to natural polyphenols, the abundant phenol-like groups on h-GQDs are demonstrated to be the active components exerting antioxidative effects. Further exhaustive mechanistic investigations indicate that the ultrahigh antioxidative activity of h-GQDs originates not solely from the phenol-like groups, but also from the synergy between adjacent phenol-like groups, as well as the removal of unfavorable carbonyl groups on h-GQDs. In AKI mice, h-GQDs can effectively protect the kidneys from oxidative injury with only a one-sixteenth dose of the clinical antioxidant
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.