Evidence map›Paper›PMID 34094377›Full record

ArticleChemical science2020

Construction of a chiral artificial enzyme used for enantioselective catalysis in live cells.

Ya Zhou, Weili Wei, Fengchao Cui, Zhengqing Yan, Yuhuan Sun, Jinsong Ren, Xiaogang Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Biomimetic Chiral Nanomaterials with Selective Catalysis Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ya ZhouLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 China xqu@ciac.ac.cn.
Weili WeiLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 China xqu@ciac.ac.cn.
Fengchao CuiLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 China xqu@ciac.ac.cn.
Zhengqing YanLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 China xqu@ciac.ac.cn.
Yuhuan SunLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 China xqu@ciac.ac.cn.
Jinsong RenLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 China xqu@ciac.ac.cn.ORCID https://orcid.org/0000-0002-7506-627X
Xiaogang QuLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 China xqu@ciac.ac.cn.ORCID https://orcid.org/0000-0003-2868-3205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanozymes as a newcomer in the artificial enzyme family have shown several advantages over natural enzymes such as their high stability in harsh environments, facile production on large scale, long storage time, low costs, and higher resistance to biodegradation. However, compared with natural enzymes, it is still a great challenge to design a nanozyme with high selectivity, especially high enantioselectivity. It is highly desirable and demanding to develop chiral nanozymes with high and on-demand enantioselectivity for practical applications. Herein, we present an unprecedented approach to construct chiral artificial peroxidase with ultrahigh enantioselectivity. Inspired by the structure of the natural enzyme horseradish peroxidase (HRP), we have constructed a series of stereoselective nanozymes (Fe

Identifiers

PMID34094377
PMCPMC8162767

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.