ArticleChemical science2020
Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 81 citations in OpenAlex.
- Insights into the Controlled Formation of Zr-Based Metal-Organic Gels: Linking Macroscopic Properties with Molecular Information from Solution State NMR.Angewandte Chemie (International ed. in English) · 2026Article
- Encapsulation of Snail Slime in Metal-Organic Framework ZIF-8.Journal of functional biomaterials · 2025Article
- Multi-Functional Polydopamine-Mucin Hollow Particles Provide Tunable Shell Permeability, ROS Scavenging, Tissue Adhesion, and Lubricity for Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Harnessing curcumin in a multifunctional biodegradable metal-organic framework (bio-MOF) for targeted colorectal cancer theranostics.Drug delivery and translational research · 2025Article
- A polymer deposition-mediated surface-charge reformation strategy: reversing the MOF biomineralization behavior.Chemical science · 2024Article
- Metal-organic frameworks (MOFs) and their derivatives as emerging biomaterials for the treatment of osteoarthritis.Frontiers in pharmacology · 2024Review
- Biomineralization of Human Genomic DNA into ZIF-8, a Zeolite-Like Metal-Organic Framework.Sovremennye tekhnologii v meditsine · 2024Article
- A π-conjugated covalent organic framework enables interlocked nickel/photoredox catalysis for light-harvesting cross-coupling reactions.Chemical science · 2023Article
- Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycosaminoglycans (GAGs) are biomacromolecules necessary for the regulation of different biological functions. In medicine, GAGs are important commercial therapeutics widely used for the treatment of thrombosis, inflammation, osteoarthritis and wound healing. However, protocols for the encapsulation of GAGs in MOFs carriers are not yet available. Here, we successfully encapsulated GAG-based clinical drugs (heparin, hyaluronic acid, chondroitin sulfate, dermatan sulfate) and two new biotherapeutics in preclinical stage (GM-1111 and HepSYL proteoglycan) in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The resultant GAG@MOF biocomposites present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which influences the drug-release kinetics upon applying an acidic stimulus. For a selected system, heparin@MOF, the released therapeutic retained its antithrombotic activity while the MOF shell effectively protects the drug from heparin lyase. By using different MOF shells, the present approach enables the preparation of GAG-based biocomposites with tunable properties such as encapsulation efficiency, protection and release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.