ArticleChemical science2020
Nickel catalysis enables convergent paired electrolysis for direct arylation of benzylic C-H bonds.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Noninnocent Deep Eutectic Solvents Enable Selective, Sustainable Nickel-Catalyzed Cross-Electrophile Couplings to Diarylmethanes.ChemSusChem · 2026Article
- Direct visualization of inner-sphere electrocatalytic reactions as they occur at detachable electrochemical interfaces.Chemical science · 2026Article
- Paired Pulsed Decarboxylative Hydroxylation Designed by Online Electrochemistry-Mass Spectrometry.Journal of the American Chemical Society · 2025Article
- Electrochemical deamination functionalizationChemical science · 2025Review
- Switchable electrochemical pathways for the selective C(spNature communications · 2025Article
- CoONature communications · 2025Article
- Electro/Ni Dual-Catalyzed Decarboxylative C(spAngewandte Chemie (International ed. in English) · 2024Article
- Nickel/biimidazole-catalyzed electrochemical enantioselective reductive cross-coupling of aryl aziridines with aryl iodides.Nature communications · 2023Article
- Electrochemical synthesis of heterodehydro[7]helicenes.Communications chemistry · 2022Article
- Paired electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling between α-chloroesters and aryl bromides.Nature communications · 2022Article
- Electro-Synthesis of Organic Compounds with Heterogeneous Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry.Nature communications · 2022Article
- Directed Ni-Catalyzed Reductive Arylation of Aliphatic C-H Bonds.Organic letters · 2022Article
- Aroyl Fluorides as Bifunctional Reagents for Dearomatizing Fluoroaroylation of Benzofurans.Journal of the American Chemical Society · 2022Article
- Recent Advances in C(spACS organic & inorganic Au · 2022Review
- Traditional and sustainable approaches for the construction of C-C bonds by harnessing C-H arylation.Nature communications · 2022Review
- Transition metal-catalyzed organic reactions in undivided electrochemical cells.Chemical science · 2021Review
- Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols.Angewandte Chemie (International ed. in English) · 2021Article
- Redox-Neutral Cross-Coupling Amination with WeakJACS Au · 2021Article
- Electrocatalysis as an enabling technology for organic synthesis.Chemical Society reviews · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Convergent paired electrosynthesis is an energy-efficient approach in organic synthesis; however, it is limited by the difficulty to match the innate redox properties of reaction partners. Here we use nickel catalysis to cross-couple the two intermediates generated at the two opposite electrodes of an electrochemical cell, achieving direct arylation of benzylic C-H bonds. This method yields a diverse set of diarylmethanes, which are important structural motifs in medicinal and materials chemistry. Preliminary mechanistic study suggests oxidation of a benzylic C-H bond, Ni-catalyzed C-C coupling, and reduction of a Ni intermediate as key elements of the catalytic cycle.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.