ArticleChemical science2020
Activation chemistry drives the emergence of functionalised protocells.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Influence of Phosphate Activation Chemistry on the Selection of the Primordial Genetic Alphabet.Journal of the American Chemical Society · 2026Article
- Chemical Routes to Primitive Membranes: Prebiotic Lipid Formation at the Origin of Life.Life (Basel, Switzerland) · 2026Review
- On the Origin of Life on Earth: The Nanozymes Hypothesis, and More.Research (Washington, D.C.) · 2025Review
- Chemically Driven Division of Protocells by Membrane Budding.Journal of the American Chemical Society · 2024Article
- A Surface Hydrothermal Source of Nitriles and Isonitriles.Life (Basel, Switzerland) · 2024Article
- Ring Opening of Glycerol Cyclic Phosphates Leads to a Diverse Array of Potentially Prebiotic Phospholipids.Journal of the American Chemical Society · 2023Article
- Hybrid organic-inorganic structures trigger the formation of primitive cell-like compartments.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Confinement effect on hydrolysis in small lipid vesicles.Chemical science · 2023Article
- Elucidating N-acyl amino acids as a model protoamphiphilic system.Communications chemistry · 2022Article
- Article
- Dehydration Enhances Prebiotic Lipid Remodeling and Vesicle Formation in Acidic Environments.ACS central science · 2022Article
- Influence of Metal Ions on Model Protoamphiphilic Vesicular Systems: Insights from Laboratory and Analogue Studies.Life (Basel, Switzerland) · 2021Article
- Self-reproducing catalytic micelles as nanoscopic protocell precursors.Nature reviews. Chemistry · 2021Review
- Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells.Journal of the American Chemical Society · 2021Article
- Scum of the Earth: A Hypothesis for Prebiotic Multi-Compartmentalised Environments.Life (Basel, Switzerland) · 2021Article
- When Is a Reaction Network a Metabolism? Criteria for Simple Metabolisms That Support Growth and Division of Protocells.Life (Basel, Switzerland) · 2021Article
- Article
- Illuminating Life's Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules.Journal of the American Chemical Society · 2021Review
- The "Water Problem"(Life (Basel, Switzerland) · 2021Review
- Spontaneous emergence of membrane-forming protoamphiphiles from a lipid-amino acid mixture under wet-dry cycles.Chemical science · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The complexity of the simplest conceivable cell suggests that the chemistry of prebiotic mixtures needs to be explored to understand the intricate network of prebiotic reactions that led to the emergence of life. Early cells probably relied upon compatible and interconnected chemistries to link RNA, peptides and membranes. Here we show that several types of vesicles, composed of prebiotically plausible mixtures of amphiphiles, spontaneously form and sustain the methyl isocyanide-mediated activation of amino acids, peptides and nucleotides. Activation chemistry also drives the advantageous conversion of reactive monoacylglycerol phosphates into inert cyclophospholipids, thus supporting their potential role as major constituents of protocells. Moreover, activation of prebiotic building blocks within fatty acid-based vesicles yields lipidated species capable of localising to and functionalising primitive membranes. Our findings describe a potentially prebiotic scenario in which the components of primitive cells undergo activation and provide new species that might have enabled an increase in the functionality of protocells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.