ArticleChemical science2020
Challenging the Ostwald rule of stages in mechanochemical cocrystallisation.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Synchrotron X-ray powder diffraction validation of real-time in situ terahertz-Raman monitoring of resonant acoustic mixing cocrystallization.Communications chemistry · 2026Article
- New Insights into the Structure and Thermodynamic Stability of Polymorphs I and II of the Nicotinamide:Adipic Acid Co-Crystal: A BEST-CSP Study.Crystal growth & design · 2026Article
- Control of site-specific deprotonation through mechanochemical interconversion of two ionic cocrystal forms of resveratrol.Journal of materials chemistry. B · 2026Article
- Polymorphism in Cannabinol Piperazine Cocrystals: Structural, Morphological, and Energetic Perspectives.Crystal growth & design · 2025Article
- Deciphering the complexities of crystalline state(s) with molecular simulations.Communications chemistry · 2025Review
- High-throughput encapsulated nanodroplet screening for accelerated co-crystal discovery.Chemical science · 2025Article
- Listening to the Formation of Polymorphs in a Ball Mill.Analytical chemistry · 2025Article
- Kinetics of the mechanochemical transformations in the "glycine - oxalic acid dihydrate" system revisited: The role of water.Frontiers in chemistry · 2025Article
- Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs.Pharmaceutics · 2022Review
- Article
- Time-Resolved In Situ Monitoring of Mechanochemical Reactions.Angewandte Chemie (International ed. in English) · 2022Review
- Structural Analysis of Molecular Materials Using the Pair Distribution Function.Chemical reviews · 2022Review
- Simplifying and expanding the scope of boron imidazolate framework (BIF) synthesis using mechanochemistry.Chemical science · 2021Article
- Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications.Acta pharmaceutica Sinica. B · 2021Review
- Spontaneously formed gradient chemical compositional structures of niobium doped titanium dioxide nanoparticles enhance ultraviolet- and visible-light photocatalytic performance.Scientific reports · 2021Article
- Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals.Pharmaceutics · 2021Review
- A Contribution to the Solid State Forms of Bis(demethoxy)curcumin: Co-Crystal Screening and Characterization.Molecules (Basel, Switzerland) · 2021Article
- Tribochemistry, Mechanical Alloying, Mechanochemistry: What is in a Name?Frontiers in chemistry · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanochemistry provides an efficient, but still poorly understood route to synthesize and screen for polymorphs of organic solids. We present a hitherto unexplored effect of the milling assembly on the polymorphic outcome of mechanochemical cocrystallisation, tentatively related to the efficiency of mechanical energy transfer to the milled sample. Previous work on mechanochemical cocrystallisation has established that introducing liquid or polymer additives to milling systems can be used to direct polymorphic behavior, leading to extensive studies how the amount and nature of grinding additive affect reaction outcome and polymorphism. Here, focusing on a model pharmaceutical cocrystal of nicotinamide and adipic acid, we demonstrate that changes to the choice of milling media (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.