ReviewChemical science2020
Walking metals: catalytic difunctionalization of alkenes at nonclassical sites.
Review in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Modular Access to α-Tertiary Amines: Electrochemical Tandem Di-Functionalization of Olefins With Ammonia Surrogates and Amino Acids.Angewandte Chemie (International ed. in English) · 2026Article
- Alkyne migratory functionalization via C(spNature communications · 2026Article
- Palladium-catalyzed asymmetric migratory diarylation of unactivated directing-group-free internal alkenes.Nature communications · 2026Article
- Diastereo- and enantioselective 1,3-hydrofunctionalization of trisubstituted alkenes by a directing relay.Nature chemistry · 2026Article
- Pd(II)/PIDA-Enabled Migratory Triple Functionalization of Terminal Alkenes via a 1,2-C/Pd(IV) Dyotropic Rearrangement.Angewandte Chemie (International ed. in English) · 2025Article
- Ligand-modulated regiodivergent alkenylboration of allylarenes: Reaction development and mechanistic study.Fundamental research · 2025Article
- Palladium-Catalyzed Dual CspAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Photocatalytic 1,3-difluoroalkylcarboxylation of alkenes by triple kinetic-controlled radical self-ordering.Chemical science · 2025Article
- Ni-catalysed remote C(spNature reviews. Chemistry · 2024Review
- Regiodivergent Radical-Relay Alkene Dicarbofunctionalization.Journal of the American Chemical Society · 2024Article
- Enantioselective Aminosilylation of Alkenes by Palladium/Ming-Phos-Catalyzed Tandem Narasaka-Heck/Silylation Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Catalytic 1,1-diazidation of alkenes.Nature communications · 2024Article
- NiH-catalyzed C-N bond formation: insights and advancements in hydroamination of unsaturated hydrocarbons.Chemical science · 2024Review
- Selective C-H Activation of Unprotected Allylamines by Control of Catalyst Speciation.Chem catalysis · 2023Article
- Nickel-Catalyzed Alkene Difunctionalization as a Method for Polymerization.Journal of the American Chemical Society · 2023Article
- Multi-site programmable functionalization of alkenes via controllable alkene isomerization.Nature chemistry · 2023Article
- Article
- Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes.ACS catalysis · 2023Article
- Dual Ruthenium-Catalyzed Alkene Isomerization-Hydrogen Auto-Transfer Unlocks Skipped Dienes as Pronucleophiles for Enantioselective Alcohol C-H Allylation.Journal of the American Chemical Society · 2023Article
- NiH-catalyzed anti-Markovnikov hydroamidation of unactivated alkenes with 1,4,2-dioxazol-5-ones for the direct synthesis of N-alkyl amides.Communications chemistry · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Migration of metals along a carbon chain is triggered by two of the most common organometallic elementary steps - β-hydride (β-H) elimination and alkene hydrometallation. This process heralds a new future for creating bonds at carbon sites that fall outside the tenets of the conventional wisdom for reactivity and bond formation, and provides an opportunity to leverage β-H elimination to advance the very reaction of alkene difunctionalization it is intrinsically predestined to disrupt. Almost four decades since its genesis, the early adventure for alkene difunctionalization by metal migration was sporadic, and its later development went on a hiatus primarily due to original impetus on arresting β-H elimination for vicinal alkene difunctionalization. With the recent surge on alkene difunctionalization, efforts have been gradually shifting to harnessing the process of β-H elimination to difunctionalize alkenes at sites other than the classical vicinal carbons, termed henceforth nonclassical reaction sites for pedagogical simplicity. In this review article, we extricate and examine the origin and the development of such reactions over the years. This review covers a wide range of reactions for the difunctionalization of alkenes at geminal (1,1), allylic (1,3) and remote (1,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.