ReviewChemical science2020
Atomic engineering of single-atom nanozymes for enzyme-like catalysis.
Review in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Application of Single-Atom Nanozymes in the Detection of Small Biomolecules: A Review.Molecules (Basel, Switzerland) · 2026Review
- 3D-printed hollow microneedle-based electrochemical sensor for wireless glucose monitoring.The Analyst · 2026Article
- Preparation and biomedical applications of single-metal atom catalysts.Nature protocols · 2026Review
- Copper-based single-atom nanozymes: from fundamental insights to biomedical applications.Chemical science · 2026Review
- Polyvinylpyrrolidone-modified iron single-atom nanozymes: preparation and application to highly sensitive immunomagnetic bead assay for tetracycline detection.Mikrochimica acta · 2026Article
- Nanozyme-Based Anti-Inflammatory Strategies in Cardiovascular Disease Management: Clinical Prospects and Challenges.International journal of nanomedicine · 2026Review
- Nanozyme-Driven Ferroptosis-Cuproptosis Interplay in Lung Cancer.International journal of nanomedicine · 2026Review
- Constructing Dual-Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Enhanced Antibacterial Efficacy of Copper Single-Atom Catalysts on a Two-Dimensional Boron Nitride Platform.ACS nano · 2025Article
- Emerging green-synthesized nanozymes for microbial applications: toward sustainable antimicrobial technologies.World journal of microbiology & biotechnology · 2025Review
- Spatial Coordination Structure-Driven Enzyme-Like Selectivity in Single-Atom Nanozymes.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Coordination Geometry Tuning in a Single-Atom Nanozyme to Mimic Metalloenzymes with Nonplanar Active Site.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Choline Oxidase-Incorporated ATRP-Based Cerium Nanogels as Nanozymes for Colorimetric Detection of Hydrogen Peroxide and Choline.Biosensors · 2024Article
- Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects.Nature communications · 2024Article
- Uniform PtCoRuRhFe high-entropy alloy nanoflowers: Multi-site synergistic signal amplification for colorimetric assay of captopril.Mikrochimica acta · 2024Article
- Article
- Approach of a small protein to the biomimetic bis-(μ-oxo) dicopper active-site installed in MOF-808 pores with restricted access perturbs substrate selectivity of oxidase nanozyme.Chemical science · 2024Article
- Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity.Nature communications · 2024Article
- 3D-Printed Flexible Microfluidic Health Monitor forACS sensors · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enzyme mimics, especially nanozymes, play a crucial role in replacing natural enzymes for diverse applications related to bioanalysis, therapeutics and other enzyme-like catalysis. Nanozymes are catalytic nanomaterials with enzyme-like properties, which currently face formidable challenges with respect to their intricate structure, properties and mechanism in comparison with enzymes. The latest emergence of single-atom nanozymes (SAzymes) undoubtedly promoted the nanozyme technologies to the atomic level and provided new opportunities to break through their inherent limitations. In this perspective, we discuss key aspects of SAzymes, including the advantages of the single-site structure, and the derived synergetic enhancements of enzyme-like activity, catalytic selectivity and the mechanism, as well as the superiority in biological and catalytic applications, and then highlight challenges that SAzymes face and provide relevant guidelines from our point of view for the rational design and extensive applications of SAzymes, so that SAzyme may achieve its full potential as the next-generation nanozyme.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.