Evidence map›Paper›PMID 34094195›Full record

ArticleChemical science2020

Discovery and biosynthesis of bosamycins from

Zi Fei Xu, Sheng Tao Bo, Mei Jing Wang, Jing Shi, Rui Hua Jiao, Yang Sun, Qiang Xu, Ren Xiang Tan, Hui Ming Ge

Abstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zi Fei XuState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.
Sheng Tao BoState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.
Mei Jing WangState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.
Jing ShiState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.
Rui Hua JiaoState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.
Yang SunState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.
Qiang XuState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.
Ren Xiang TanState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.
Hui Ming GeState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University 210023 P. R. China rxtan@nju.edu.cn hmge@nju.edu.cn.ORCID https://orcid.org/0000-0002-0468-808X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonribosomal peptides (NRPs) that are synthesized by modular megaenzymes known as nonribosomal peptide synthetases (NRPSs) are a rich source for drug discovery. By targeting an unusual NRPS architecture, we discovered an unusual biosynthetic gene cluster (

Identifiers

PMID34094195
PMCPMC8161544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.