ArticleChemical science2020
Good's buffers have various affinities to gold nanoparticles regulating fluorescent and colorimetric DNA sensing.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- Ion-Specific Modulation of Ferri/Ferrocyanide-Driven Gold Dissolution Uncovered by Quantitative Quartz Crystal Microbalance Analysis.Analytical chemistry · 2026Article
- Influence of Gold Nanoparticles on eNOS Localization in Gill Tissues: Advancements in Immunofluorescence Techniques.ACS omega · 2024Article
- Facile Determination of Aluminum Content in Industrial Brine by Investigating the Effects of Buffer Systems.ChemistryOpen · 2024Article
- Feasibility of NAD(P)/NAD(P)H as redox agents in enzymatic plasmonic gold nanostar assays for galactose quantification.Royal Society open science · 2023Article
- Investigation of the Influence of Wound-Treatment-Relevant Buffer Systems on the Colloidal and Optical Properties of Gold Nanoparticles.Nanomaterials (Basel, Switzerland) · 2023Article
- A Label-Free, Mix-and-Detect ssDNA-Binding Assay Based on Cationic Conjugated Polymers.Biosensors · 2023Article
- A Dihydropyridine Derivative as a Highly Selective Fluorometric Probe for Quantification of AuSensors (Basel, Switzerland) · 2022Article
- Biosensing with DNAzymes.Chemical Society reviews · 2021Review
- A study on the high efficiency reduction ofRSC advances · 2021Article
- Detection of chloramphenicol with an aptamer-based colorimetric assay: critical evaluation of specific and unspecific binding of analyte molecules.Mikrochimica acta · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Citrate-capped gold nanoparticles (AuNPs) are highly important for sensing, drug delivery, and materials design. Many of their reactions take place in various buffers such as phosphate and Good's buffers. The effect of buffer on the surface properties of AuNPs is critical, yet this topic has not been systematically explored. Herein, we used halides such as fluoride, chloride, and bromide as probes to measure the relative adsorption strength of six common buffers. Among them, HEPES had the highest adsorption affinity, while MES, citrate and phosphate were weakly adsorbed with an overall ranking of HEPES > PIPES > MOPS > MES > citrate, phosphate. The adsorption strength was reflected from the inhibited adsorption of DNA and from the displacement of pre-adsorbed DNA. This conclusion is also supported by surface enhanced Raman spectroscopy. Furthermore, some buffer molecules did not get adsorbed instantaneously, and the MOPS buffer took up to 1 h to reach equilibrium. Finally, a classic label-free AuNP-based colorimetric sensor was tested. Its sensitivity increased by 15.7-fold when performed in a MES buffer compared to a HEPES buffer. This study has articulated the importance of buffer for AuNP-based studies and how it can improve sensors and yield more reproducible experimental systems.
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Registered trials
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