ArticleChemical science2020
A methylation platform of unconventional inert aryl electrophiles: trimethylboroxine as a universal methylating reagent.
Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Investigation of the Adsorption and Reactions of Methyl Radicals on Transition Metal (M = Co, Ni, Pd, Pt) (111) Surfaces in Aqueous Suspensions.Molecules (Basel, Switzerland) · 2025Article
- Dual role of nitroarenes as electrophiles and arylamine surrogates in Buchwald-Hartwig-type coupling for C-N bond construction.Chemical science · 2024Article
- Well-Defined, Air- and Moisture-Stable Palladium-Imidazo[1,5-Catalysis science & technology · 2022Article
- Palladium-catalyzed nucleomethylation of alkynes for synthesis of methylated heteroaromatic compounds.Chemical science · 2022Article
- Leveraging the 1,3-azadiene-anhydride reaction for the synthesis of functionalized piperidines bearing up to five contiguous stereocenters.RSC advances · 2021Article
- Build-up of double carbohelicenes using nitroarenes: dual role of the nitro functionality as an activating and leaving group.Chemical science · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylation is one of the most fundamental conversions in medicinal and material chemistry. Extension of substrate types from aromatic halides to other unconventional aromatic electrophiles is a highly important yet challenging task in catalytic methylation. Disclosed herein is a series of transition metal-catalyzed methylations of unconventional inert aryl electrophiles using trimethylboroxine (TMB) as the methylating reagent. This transformation features a broad substrate type, including nitroarenes, benzoic amides, benzoic esters, aryl cyanides, phenol ethers, aryl pivalates and aryl fluorides. Another important merit of this work is that these widespread "inert" functionalities are capable of serving as directing or activating groups for selective functionalization of aromatic rings before methylation, which greatly expands the connotation of methylation chemistry.
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Registered trials
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