Evidence map›Paper›PMID 34094035›Full record

ArticleIranian journal of basic medical sciences2021

Investigating the basis for the antidepressant effects of

Tong Liu, Ning Zhou, Yangang Cao, Ruihao Xu, Zhen Liu, Xiaoke Zheng, Weisheng Feng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tong LiuSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Ning ZhouSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Yangang CaoSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Ruihao XuSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Zhen LiuSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Xiaoke ZhengSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Weisheng FengSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
First Affiliated Hospital of Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMATERIALS AND

methodsUrine samples from C57BL/6 mice were analyzed based on ultra performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-Q/TOF-MS). Then, we investigated the therapeutic effects of GS and Tax in depression models

resultsCorticosterone exposure significantly increased serum levels of corticosterone but decreased serum levels of 5-hydroxytryptamine and sucrose consumption (

conclusionThese findings indicate that flavonoids form the pharmacodynamic basis of the antidepressant effects of GS. Moreover, our findings highlight that integrated metabolomics provides a powerful tool to study the mechanisms and material basis of Chinese herbs.

Indexed as

BiomarkerDepressionFlavonoidsMetabolic profilingMetabolomics

Identifiers

PMID34094035
PMCPMC8143708
OpenAlexW3155493039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.