ArticleStatistics in biosciences2021
Testing for mediation effect with application to human microbiome data.
Article in Statistics in biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Total and different types of olive oil consumption, gut microbiota, and cognitive function changes in older adults.Microbiome · 2026Article
- Microbiome mediation analysis: methods, assumptions, and practical considerations.Frontiers in cellular and infection microbiology · 2026Review
- HILAMA: High-dimensional multi-omics mediation analysis with latent confounding.BMC medical research methodology · 2025Article
- Exploring the role of microbiome in cystic fibrosis clinical outcomes through a mediation analysis.mSystems · 2025Article
- Multimedia: multimodal mediation analysis of microbiome data.Microbiology spectrum · 2025Article
- CRAmed: a conditional randomization test for high-dimensional mediation analysis in sparse microbiome data.Bioinformatics (Oxford, England) · 2025Article
- Chain-mediated effects of career self-efficacy and career planning between social support and career anxiety in college soccer players.Frontiers in psychology · 2025Article
- A novel and robust feature selection method with FDR control for omics-wide association analysis.PloS one · 2025Article
- multimedia: Multimodal Mediation Analysis of Microbiome Data.bioRxiv : the preprint server for biology · 2024Article
- Article
- Gut microbiota metabolically mediate intestinal helminth infection in Zebrafish.bioRxiv : the preprint server for biology · 2024Article
- Collider bias correction for multiple covariates in GWAS using robust multivariable Mendelian randomization.PLoS genetics · 2024Article
- High-dimensional quantile mediation analysis with application to a birth cohort study of mother-newborn pairs.Bioinformatics (Oxford, England) · 2024Article
- Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans.Advances in nutrition (Bethesda, Md.) · 2023Review
- PhyloMed: a phylogeny-based test of mediation effect in microbiome.Genome biology · 2023Article
- HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data.BMC bioinformatics · 2022Article
- Statistical challenges in longitudinal microbiome data analysis.Briefings in bioinformatics · 2022Review
- A new approach to testing mediation of the microbiome at both the community and individual taxon levels.Bioinformatics (Oxford, England) · 2022Article
- Article
- Mediation analysis for survival data with high-dimensional mediators.Bioinformatics (Oxford, England) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Mediation analysis has been commonly used to study the effect of an exposure on an outcome through a mediator. In this paper, we are interested in exploring the mediation mechanism of microbiome, whose special features make the analysis challenging. We consider the isometric logratio transformation of the relative abundance as the mediator variable. Then, we present a de-biased Lasso estimate for the mediator of interest and derive its standard error estimator, which can be used to develop a test procedure for the interested mediation effect. Extensive simulation studies are conducted to assess the performance of our method. We apply the proposed approach to test the mediation effect of human gut microbiome between the dietary fiber intake and body mass index.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.