Evidence map›Paper›PMID 34093864›Full record

ArticleTheranostics2021

Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer.

Xuan Qin, Jia Li, Shiqing Wang, Jianying Lv, Fangkun Luan, Yanhua Liu, Yanan Chen, Xiaosu Chen, Yujia Zhao, Jingjin Zhu and 6 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Article
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  10. Cancer and neurotransmitter receptors.Chinese medical journal · 2025
    Review
  11. Article
  12. Article
  13. Article
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  16. Article
  17. A chronic stress-induced microbiome perturbation, highly enriched inInternational journal of medical sciences · 2024
    Article
  18. Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Xuan QinSchool of Medicine, Nankai University, Tianjin 300071, China.
Jia LiSchool of Medicine, Nankai University, Tianjin 300071, China.
Shiqing WangSchool of Medicine, Nankai University, Tianjin 300071, China.
Jianying LvSchool of Medicine, Nankai University, Tianjin 300071, China.
Fangkun LuanSchool of Medicine, Nankai University, Tianjin 300071, China.
Yanhua LiuSchool of Medicine, Nankai University, Tianjin 300071, China.
Yanan ChenSchool of Medicine, Nankai University, Tianjin 300071, China.
Xiaosu ChenSchool of Medicine, Nankai University, Tianjin 300071, China.
Yujia ZhaoSchool of Medicine, Nankai University, Tianjin 300071, China.
Jingjin ZhuSchool of Medicine, Nankai University, Tianjin 300071, China.
Yongjun PiaoSchool of Medicine, Nankai University, Tianjin 300071, China.
Wenwen ZhangResearch Institute of Obstetrics and Gynecology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin 300100, China.
Yi ShiSchool of Medicine, Nankai University, Tianjin 300071, China.
Rong XiangSchool of Medicine, Nankai University, Tianjin 300071, China.
Pengpeng QuDepartment of Gynecological Oncology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin 300100, China.
Longlong WangSchool of Medicine, Nankai University, Tianjin 300071, China.
Nankai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Stress, PhysiologicalAdenocarcinomaAnimalsBehavior Rating ScaleCell Line, TumorCell MovementCell ProliferationDisease ProgressionEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticGenetic TestingHumansImmunohistochemistryMiceMice, Inbred NODReceptors, SerotoninReceptors, Serotonin, 5-HT1Serotoninserotonin 1E receptorchronic stressHTR1Eovarian cancerserotoninSRC

Identifiers

PMID34093864
PMCPMC8171092
OpenAlexW3162817561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.