Evidence map›Paper›PMID 34093846›Full record

ArticleTheranostics2021

Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.

Lingjuan Chen, Hongqi Chen, Junjie Ye, Yan Ge, Haiyan Wang, Enyong Dai, Jinghua Ren, Weilin Liu, Congrong Ma, Songguang Ju and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
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  8. Article
  9. Review
  10. Oncolytic viruses: advanced strategies in cancer therapy.Signal transduction and targeted therapy · 2026
    Review
  11. Article
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  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Lingjuan ChenAllegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.
Hongqi ChenUPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Junjie YeAllegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.
Yan GeUPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Haiyan WangUPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Enyong DaiUPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Jinghua RenUPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Weilin LiuUPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Congrong MaUPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Songguang JuDepartment of Immunology, School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou, Jiangsu Province, China.
Z Sheng GuoUPMC Hillman Cancer Center and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Zuqiang LiuAllegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.
David L BartlettAllegheny Health Network Cancer Institute, Pittsburgh, PA 15212, USA.
Soochow University · CNDrexel University · USAllegheny Health Network · USCentral South University · CNHubei Cancer Hospital · CNShanghai Jiao Tong University · CNUnion Hospital · CNWuhan University · CN

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenocarcinomaAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorChemokinesColonic NeoplasmsDisease Models, AnimalFemaleGenetic VectorsGranzymesHumansImmunotherapyInterferon-gammaInterleukin-12Interleukin-2ChemokinesGranzymesInterferon-gammaInterleukin-12Interleukin-2Interleukin-23PerforinTumor Necrosis Factor-alphacancer immunotherapyefficacy.IL-23oncolytic virustumor microenvironment

Identifiers

PMID34093846
PMCPMC8171085
OpenAlexW3159738532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.