ArticleTheranostics2021
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study.
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Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
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Who cites it
50 citing papers in PubMed, 82 citations in OpenAlex.
- Adolescent intermittent ethanol exacerbates amyloid-β with age in the dorsal hippocampus of female TgF344-AD rats.Journal of Alzheimer's disease : JAD · 2026Article
- Dual association patterns between microglial activation and neuronal health in Alzheimer's disease: a whole-brain MRSI/PET study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Early-life cognitive intervention preserves brain function in aged TgF344-AD rats with sex-specific effects.iScience · 2026Article
- Glial cells are involved in day-night protein dysregulation in the hippocampus of a mouse model of Alzheimer's disease.Scientific reports · 2025Article
- TSPO contributes to neuropathology and cognitive deficits in Alzheimer's disease.Journal of neuroinflammation · 2025Article
- Adolescent intermittent ethanol exacerbates Aβ with age in the dorsal hippocampus of female TgF344-AD rats.bioRxiv : the preprint server for biology · 2025Article
- Sex-specific effects of chronic alcohol consumption across the lifespan in the transgenic Alzheimer's Disease (TgF344-AD) rat model.Brain, behavior, and immunity · 2025Article
- GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration.Neuron · 2025Article
- The role of ultrasonic vocalizations in rat laryngological investigations.Physiology & behavior · 2025Review
- MRI detects blood-brain barrier alterations in a rat model of Alzheimer's disease and lung infection.Npj imaging · 2025Article
- Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats.Frontiers in aging neuroscience · 2025Article
- Innovations in Alzheimer's disease diagnostic technologies: clinical prospects of novel biomarkers, multimodal integration, and non-invasive detection.Frontiers in neurology · 2025Review
- Circadian Alterations in Brain Metabolism Linked to Cognitive Deficits During Hepatic Ischemia-Reperfusion Injury Using [Biomedicines · 2024Article
- Relationship Between Reactive Astrocytes, by [Molecular neurobiology · 2024Article
- The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing.Translational neurodegeneration · 2024Review
- High caloric intake improves neuronal metabolism and functional hyperemia in a rat model of early AD pathology.Theranostics · 2024Article
- Neuroimaging techniques, gene therapy, and gut microbiota: frontier advances and integrated applications in Alzheimer's Disease research.Frontiers in aging neuroscience · 2024Review
- Recent Advancements in the Treatment of Alzheimer's Disease: A Multitarget-directed Ligand Approach.Current medicinal chemistry · 2024Review
Corrections and comments
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Authors and funding
27 authors at 11 institutions in 6 countries.
Aisling M ChaneyFaculty of Biology, Medicine and Health, School of Health Sciences, Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK.
Francisco R Lopez-PiconMediCity Research Laboratory, University of Turku, Turku, Finland.
Sophie SerrièreUMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Rui WangDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Daniela BochicchioWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Samuel D WebbSchool of Healthcare Science, Department of Life Sciences, Manchester Metropolitan University, Manchester, UK.
Matthias VandesquilleWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Michael K HarteFaculty of Biology, Medicine and Health, School of Health Sciences, Division of Pharmacy and Optometry, University of Manchester, Manchester, UK.
Christina GeorgiadouWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Catherine LawrenceFaculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience and Experimental Psychology, University of Manchester, M13 9PL, UK.
Julie BussonUMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Johnny VercouillieUMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Clovis TauberCERRP, Centre d'Etudes et de Recherches sur les Radiopharmaceutiques, Tours, France.
Frédéric BuronICOA, UMR CNRS 7311, Université d'Orléans, Orléans, France.
Sylvain RoutierICOA, UMR CNRS 7311, Université d'Orléans, Orléans, France.
Tristan ReekieSchool of Chemistry, University of Sydney, NSW, Australia.
Anniina SnellmanMediCity Research Laboratory, University of Turku, Turku, Finland.
Michael KassiouSchool of Chemistry, University of Sydney, NSW, Australia.
Johanna RokkaTurku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland.
Karen E DaviesFaculty of Biology, Medicine and Health, School of Health Sciences, Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK.
Juha O RinneTurku PET Centre, Turku University Hospital, Turku, Finland.
Dervis A SalihDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Frances A EdwardsDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Llwyd D OrtonSchool of Healthcare Science, Department of Life Sciences, Manchester Metropolitan University, Manchester, UK.
Stephen R WilliamsFaculty of Biology, Medicine and Health, School of Health Sciences, Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK.
Sylvie ChalonUMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Hervé BoutinWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
University of Manchester · GBUniversity College London · GBInserm · FRManchester Academic Health Science Centre · GBTurku PET Centre · FIUniversity of Sydney · AUInstitut de Chimie Organique et Analytique · FRTurku University Hospital · FIUK Dementia Research Institute · GBUniversité de Tours · FRUniversité d'Orléans · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss, necessitating the development of new AD models. The transgenic (TG) TgF344-AD rat has been reported to develop age-dependent AD features including neuronal loss and neurofibrillary tangles, despite only expressing
Indexed as
Magnetic Resonance SpectroscopyPositron-Emission TomographyAgingAlzheimer DiseaseAnimalsBehavior Rating ScaleCognitive DysfunctionDisease Models, AnimalFemaleFluorine RadioisotopesFrontal LobeGliosisHippocampusImmunohistochemistryInflammationLocomotionFluorine RadioisotopesMapt protein, ratReceptors, Cholinergictau ProteinsAlzheimer's diseaseanimal modelsmagnetic resonance spectroscopyneuroinflammationpositron emission tomography
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.