Evidence map›Paper›PMID 34093566›Full record

ArticleFrontiers in immunology2021

Resolvin D1 Improves the Treg/Th17 Imbalance in Systemic Lupus Erythematosus Through miR-30e-5p.

Tao Cheng, Shuai Ding, Shanshan Liu, Xiaojing Li, Xiaojun Tang, Lingyun Sun

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Inflammation and Resolution in Obesity-Related Cardiovascular Disease.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Inflammation and resolution in obesity.Nature reviews. Endocrinology · 2025 · on this map
    Review
  13. Article
  14. Frontiers in veterinary science · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Circulating miRNAs drive personalized medicine based on subgroup classification in myasthenia gravis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tao ChengDepartment of Rheumatology and Immunology, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Shuai DingDepartment of Rheumatology and Immunology, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Shanshan LiuDepartment of Rheumatology and Immunology, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Xiaojing LiDepartment of Rheumatology and Immunology, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Xiaojun TangDepartment of Rheumatology and Immunology, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Lingyun SunDepartment of Rheumatology and Immunology, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Nanjing Drum Tower Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resolvin D1 (RvD1) prompts inflammation resolution and regulates immune responses. We explored the effect of RvD1 on systemic lupus erythematosus (SLE) and investigated the correlation between RvD1 and Treg/Th17 imbalance, which is one of the major factors contributing to the pathogenesis of disease. SLE patients and healthy controls were recruited to determine plasma RvD1 levels. MRL/

Indexed as

AdultAnimalsAnti-Inflammatory AgentsCase-Control StudiesCell DifferentiationCells, CulturedCytokinesDisease Models, AnimalDocosahexaenoic AcidsFemaleHumansInflammation MediatorsLupus Erythematosus, SystemicMaleMiceMice, Inbred MRL lprAnti-Inflammatory AgentsCytokinesDocosahexaenoic AcidsInflammation MediatorsMicroRNAsMirn30d microRNA, mouseresolvin D1miR-30e-5pregulatory T cellsResolvin D1systemic lupus erythematosusT helper 17 cells

Identifiers

PMID34093566
PMCPMC8171186
OpenAlexW3162502629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.