Evidence map›Paper›PMID 34093560›Full record

ArticleFrontiers in immunology2021

The Long Pentraxin PTX3 Controls

Fatemeh Asgari, Domenico Supino, Raffaella Parente, Nadia Polentarutti, Matteo Stravalaci, Remi Porte, Fabio Pasqualini, Marialuisa Barbagallo, Chiara Perucchini, Camilla Recordati and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Infection and drug resistance · 2026
    Review
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  6. Divergent roles for complement components C3 and C4 in controllingbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 4 countries.

Fatemeh AsgariDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Domenico SupinoDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Raffaella ParenteDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Nadia PolentaruttiDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Matteo StravalaciDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Remi PorteDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Fabio PasqualiniDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Marialuisa BarbagalloDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Chiara PerucchiniDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Camilla RecordatiDepartment of Veterinary Medicine, University of Milano, Lodi, Italy.
Elena MagriniDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Andrea MarianciniDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Federica RivaDepartment of Veterinary Medicine, University of Milano, Lodi, Italy.
Alessia GiordanoDepartment of Veterinary Medicine, University of Milano, Lodi, Italy.
Sadaf DavoudianDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Thierry RogerInfectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Epalinges, Switzerland.
Cornelis Van't VeerCenter of Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, Netherlands.
Sebastien JaillonDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Alberto MantovaniDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Andrea DoniUnit of Advanced Optical Microscopy, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Cecilia GarlandaDepartment of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
IRCCS Humanitas Research Hospital · ITHumanitas University · ITUniversity of Milan · ITAcademic Medical Center · NLUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBacterial LoadC-Reactive ProteinCytokinesFibrinFibrinogenImmunity, InnateInflammationKlebsiella InfectionsKlebsiella pneumoniaeLungMicePentraxinsSepsisSerum Amyloid P-ComponentStromal CellsC-Reactive ProteinCytokinesFibrinFibrinogenPentraxinsSerum Amyloid P-Componentcomplement – immunological terminflammationinnate immunityKlebsiella pneumoniaePentraxin 3 (PTX3)sepsis

Identifiers

PMID34093560
PMCPMC8173212
OpenAlexW3161478138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.