Evidence map›Paper›PMID 34093547›Full record

ReviewFrontiers in immunology2021

Natural Killer Cell-Derived Extracellular Vesicles: Novel Players in Cancer Immunotherapy.

Feifeng Wu, Min Xie, Marady Hun, Zhou She, Cuifang Li, Senlin Luo, Xiaoyu Chen, Wuqing Wan, Chuan Wen, Jidong Tian

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  14. The Effects of Released Exosomes from NK-92 Cells with IL15 on the Apoptosis of HL-60 Cell Line.International journal of hematology-oncology and stem cell research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Feifeng WuDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Min XieDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Marady HunDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Zhou SheDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Cuifang LiDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Senlin LuoDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiaoyu ChenDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Wuqing WanDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Chuan WenDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Jidong TianDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells are critical components of host innate immunity and function as the first line of defense against tumors and viral infection. There is increasing evidence that extracellular vesicles (EVs) are involved in the antitumor activity of NK cells. NK cell-derived EVs (NKEVs) carrying cargo such as cytotoxic proteins, microRNAs, and cytokines employ multiple mechanisms to kill tumor cells, but also exhibit immunomodulatory activity by stimulating other immune cells. Several studies have reported that NKEVs can reverse immune suppression under tolerogenic conditions and contribute to NK-mediated immune surveillance against tumors. Thus, NKEVs are a promising tool for cancer immunotherapy. In this review, we describe the biological effects and potential applications of NKEVs in antitumor immunity.

Indexed as

ImmunomodulationAnimalsBiological TransportBiomarkersCell CommunicationCytokinesCytotoxicity, ImmunologicExtracellular VesiclesGene Expression Regulation, NeoplasticHumansImmunity, InnateImmunotherapyKiller Cells, NaturalNeoplasmsSignal TransductionTumor MicroenvironmentBiomarkersCytokinescancercell-free therapyextracellular vesicleimmunotherapynatural killer cell

Identifiers

PMID34093547
PMCPMC8176011
OpenAlexW3163483456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.