ReviewFrontiers in microbiology2021
First 1000 Days of Life: Consequences of Antibiotics on Gut Microbiota.
Review in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The impact of neonatal intensive care unit antibiotics on gut bacterial microbiota of preterm infants: a systematic review.Frontiers in microbiomes · 2023Pooled it
- Early childhood antibiotic exposure, gut microbial balance and immune dysregulation.Bioinformation · 2026Article
- Very preterm gut microbiota development from the first week of life to 3.5 years of age: a prospective longitudinal multicenter study.Microbiology spectrum · 2025Article
- The nasal microbiota is a potential diagnostic biomarker for sepsis in critical care units.Microbiology spectrum · 2024Article
- Unraveling the Microbial Symphony: Impact of Antibiotics and Probiotics on Infant Gut Ecology and Antibiotic Resistance in the First Six Months of Life.Antibiotics (Basel, Switzerland) · 2024Article
- Age-associated changes in innate and adaptive immunity: role of the gut microbiota.Frontiers in immunology · 2024Review
- Effect of Serial Clinical Observation Complemented by Point-of-Care Blood Culture Volume Verification on Antibiotic Exposure in Newborns.Global pediatric health · 2024Article
- Effects of synbiotic supplementation on intestinal microbiota composition in children and adolescents with exogenous obesity: (Probesity-2 trial).Gut pathogens · 2023Article
- Microbial interactions and the homeostasis of the gut microbiome: the role ofMicrobiome research reports · 2023Review
- Article
- The Effect of Antibiotics on the Infant Gut Fungal Microbiota.Journal of fungi (Basel, Switzerland) · 2022Article
- Neonatal Programming of Microbiota Composition: A Plausible Idea That Is Not Supported by the Evidence.Frontiers in microbiology · 2022Review
- Modeling approaches for probing cross-feeding interactions in the human gut microbiome.Computational and structural biotechnology journal · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from conception to 2 years) of life. In particular, the process of gut microbiota establishment occurs within this time window. Therefore, determinants interfering with neonatal gut establishment may disrupt its physiological functions and potentially lead to negative health outcomes. Antibiotics are among perinatal determinants that can directly or indirectly affect the pattern of gut bacterial colonization, with a long-lasting impact on intestinal ecosystem functions. In this review, we will examine the impact of antibiotics on the intestinal microbiota during the perinatal period and first years of life, a key interval for development of an individual's health capital. Further, we will discuss the role of antibiotics during short- and long-term dysbiosis and their associated health consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.