Evidence map›Paper›PMID 34093437›Full record

ArticleFrontiers in endocrinology2021

Investigation of the Molecular Mechanisms by Which Endothelin-3 Stimulates Preadipocyte Growth.

An-Ci Siao, Li-Jane Shih, Yen-Yue Lin, Yi-Wei Tsuei, Yow-Chii Kuo, Hui-Chen Ku, Chih-Ping Chuu, Po-Jen Hsiao, Yung-Hsi Kao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Insights into Endothelin Receptors in Pulmonary Hypertension.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

An-Ci SiaoDepartment of Life Sciences, National Central University, Taoyuan, Taiwan.
Li-Jane ShihMedical Laboratory, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Yen-Yue LinDepartment of Life Sciences, National Central University, Taoyuan, Taiwan.
Yi-Wei TsueiDepartment of Emergency Medicine, Taoyuan Armed Forces General Hospital, Taoyuan City, Taiwan.
Yow-Chii KuoDepartment of Gastroenterology, Landseed Hospital, Taoyuan, Taiwan.
Hui-Chen KuDepartment of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Chih-Ping ChuuInstitute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan.
Po-Jen HsiaoDepartment of Life Sciences, National Central University, Taoyuan, Taiwan.
Yung-Hsi KaoDepartment of Life Sciences, National Central University, Taoyuan, Taiwan.
National Central University · TWNational Health Research Institutes · TWTaoyuan Armed Forces General Hospital · TWLandseed Hospital · TWTaipei Tzu Chi Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelins induce many biological responses, and they are composed of three peptides: ET-1, ET-2, and ET-3. Reports have indicated that ET-1 regulates cell proliferation, adipogenesis, and other cell responses and that ET-3 stimulates the growth of gastrointestinal epithelial cells and melanocytes. However, the signalling pathways of ET3 that mediate the growth of fat cells are still unclear. Using 3T3-L1 white preadipocytes, we found that ET-3 induced increases in both cell number and BrdU incorporation. Pretreatment with an ET

Indexed as

3T3-L1 CellsAdipocytesAnimalsCell ProliferationEndothelin-3MiceMitogen-Activated Protein KinasesPhosphotransferases (Alcohol Group Acceptor)Receptor, Endothelin AReceptor, Endothelin BSphingomyelin PhosphodiesteraseSphingosine KinaseEndothelin-3Mitogen-Activated Protein KinasesPhosphotransferases (Alcohol Group Acceptor)Receptor, Endothelin AReceptor, Endothelin BSphingomyelin PhosphodiesteraseSphingosine KinaseAMP-activated protein kinasec-Junendothelin-3preadipocytesignal transducer and activator of transcription

Identifiers

PMID34093437
PMCPMC8176213
OpenAlexW3161083687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.